DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EcR and Nr1h5

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_003749414.1	Gene:	Nr1h5 / 690430	RGDID:	1596077	Length:	504	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	163/494 - (32%)
Similarity:	243/494 - (49%)	Gaps:	106/494 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 GGGVGGLGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPRVQEELCLVCG 268
            ||...||..:.:.:|..|  :....:|..|.:.    ....:|..:  .||     |:|||:|||
  Rat    74 GGSWCGLDTRESSQSTYV--VVHDDEDEFPGTQ----RCRPTCSLR--WKG-----QDELCMVCG 125

  Fly   269 DRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPEC 333
            |:|||||||||||||||||||||:||:|||.||.|..|||||||||||.|||||||.||||..||
  Rat   126 DKASGYHYNALTCEGCKGFFRRSITKNAVYSCKNGGHCEMDMYMRRKCPECRLKKCKAVGMLAEC 190

  Fly   334 VVPENQCAMKRREKKAQKEKDKMTTS-------PSSQHGGNGSLASGGGQDFV-----KKEILD- 385
            ::.|.||..||. :|:.|.:..::::       ..::|..:.|.:..|.||.:     ::.:|:
  Rat   191 LLTEIQCKSKRL-RKSFKHRPTLSSAIQVEDEGTDTKHVSSTSRSGKGAQDDMTLTAEERRLLNT 254

  Fly   386 LMTCEPPQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPD 450
            ::|..  :.:.:|:  .||.|..|.                       |..|
  Rat   255 IVTAH--RKSMVPV--GEISALLQE-----------------------YSNP------------- 279

  Fly   451 ENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRY--- 512
                  ::||..::|.:||....:::|.||||.|..:..|||..|.|...:|||.|.:|:.|
  Rat   280 ------ELSFLRLSEASILHANWLMKFTKGLPGFENLTAEDQTALQKESKTEVMFLHVAQLYGGR 338

  Fly   513 ---------------------DHSSDSIFFANNRSYTRDSYKMAGMA----DNIEDLLHFCRQMF 552
                                 :|..|...: ::.::.::.|..|.:.    :.|..|.:|.|:|.
  Rat   339 DSTSGSTVRPAKPSAGTLEVHNHRGDECVY-SSENFFKEGYPSATLTGITREFIASLSYFYRRMR 402

  Fly   553 SMKVDNVEYALLTA-IVIFSDRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLS 616
            .:.:.:.||||||| .|:|||||.|:..|.||.:|...:..|..|....|..|..   .:|.|:.
  Rat   403 ELNITDTEYALLTATTVLFSDRPYLKNKQHVENLQEPVLQLLFKYSKMYHPEDPQ---HFAHLIG 464

  Fly   617 ILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVHAI 655
            .|||||||.:.::|:..:.|.|:.:|.....|.||:|::
  Rat   465 RLTELRTLSHSHSEILSTWKTKDPRLVMLFSEKWDLHSL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	66/89 (74%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	70/260 (27%)
Nr1h5	XP_003749414.1	NR_DBD_FXR	118..201	CDD:143520	63/82 (77%)
Nr1h5	XP_003749414.1	NR_LBD	247..496	CDD:299703	75/298 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351537
Domainoid	1	1.000	131	1.000	Domainoid score	I5032
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1137281at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.910