Protein Alignment EcR and RORC

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_006711547.3
• Gene: RORC / 6097
• HGNCID: 10260
• Length: 572
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 148/608 - (24%)
• Similarity: 239/608 - (39%)
• Gaps: 190/608 - (31%)

  Fly   168 GGGGIGGMGILHHANGTPNGLIGVVGGGGGVGLGVGGGGVGGLGMQHTPRSDSVNSISSGRDDLS 232
            |||...|..  |.|.|.|                 |||..|.|
Human    44 GGGKFEGQS--HQAPGPP-----------------GGGRTGCL---------------------- 67

  Fly   233 PSSSLNGYSANESCDAKKSKKGPAPRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAV 297
                          :...:||....:::...|.:|||::||.||..:||||||||||||...:|.
Human    68 --------------ELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAA 118

  Fly   298 YCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRR------------EKKAQ 350
            |.|...:.|.:|...|.:||.|||:||||:||..: .|...:.:.|:|            :::.|
Human   119 YSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRD-AVKFGRMSKKQRDSLHAEVQKQLQQRQQQ 182

  Fly   351 KEKDKMTTSPSSQHGG----------NGSL--------------------ASGGGQDF---VKKE 382
            :::..:.|.|:...|.          :|.|                    |||.|..:   :.|.
Human   183 QQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKA 247

  Fly   383 ILDLMTCE---PPQHATI-----------PLLPDEILAKC------------------------- 408
            .|:..:|.   .|:....           .|.||    :|
Human   248 GLNGASCHLEYSPERGKAEGRESFYSTGSQLTPD----RCGLRFEEHRHPGLGELGQGPDSYGSP 308

  Fly   409 QARNIPSLTYNQLAVIYKLIW-----YQDGYEQPSEEDLRR---IMSQPD----ENESQTDVSFR 461
            ..|:.|...|..|..|..|:.     |::..:...|:.||:   |.|:.:    :.:|..::..|
Human   309 SFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWER 373

  Fly   462 ---HITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFAN 523
               |:||    .:|.:|||||.|..|.::.|.|||.||||.:.||:::||.|.|:..:.::|| .
Human   374 CAHHLTE----AIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFF-E 433

  Fly   524 NRSYTRDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIF-SDRPGLEKAQLVEAIQS 587
            .:....:.::..|.::.|..:..|...:.::.....|.||.||:|:. :.||||::.:.||.:|.
Human   434 GKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQY 498

  Fly   588 YYIDTLRIYILNRHCGDSMSLVFYAKLL-----SILTELRTLGNQNAEMCFSLKLKNRKLPKFLE 647
                             ::.|.|:..|.     |||.:|...|...: :| |..::..::.:.|.
Human   499 -----------------NLELAFHHHLCKTHRQSILAKLPPKGKLRS-LC-SQHVERLQIFQHLH 544

  Fly   648 EIWDVHAIPPSVQSHLQITQEEN 670
            .|....|.|| :...|..|:.|:
Human   545 PIVVQAAFPP-LYKELFSTETES 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	40/101 (40%)
		NR_LBD_EcR	420..652	CDD:132736	66/252 (26%)
RORC	XP_006711547.3	NR_DBD_ROR	78..172	CDD:143526	40/94 (43%)
		NR_LBD_ROR_like	322..560	CDD:132737	68/262 (26%)