Protein Alignment EcR and RARB

DIOPT Version :9

• Sequence 1: NP_001163061.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001277145.1
• Gene: RARB / 5915
• HGNCID: 9865
• Length: 455
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 162/605 - (26%)
• Similarity: 246/605 - (40%)
• Gaps: 174/605 - (28%)

  Fly   141 NGHGLINSTTPSTPTTPLHLQQNLGGAGGGGIGGMGILHHANGTPNGLIGVVGGGGGVGLGVGGG 205
            |||   .:..|:|| .||.....:||.....:.|:    |.:..|:|.
Human    14 NGH---MTHYPATP-YPLLFPPVIGGLSLPPLHGL----HGHPPPSGC----------------- 53

  Fly   206 GVGGLGMQHTPRSDSVNSISSGRDDL--SPSSSLNGYSANESCDAKKSKKGPAPRVQEELCLVCG 268
                    .||...::.:.|:..::|  ||.|.|                 |.|||.:. |.||.
Human    54 --------STPSPATIETQSTSSEELVPSPPSPL-----------------PPPRVYKP-CFVCQ 92

  Fly   269 DRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPEC 333
            |::|||||....|||||||||||:.|:.:|.|...:.|.::...|.:||.|||:||..|||..|.
Human    93 DKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKES 157

  Fly   334 VVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIP 398
            |..:      |.:||.:..|.:.|.|..                         ||.|
Human   158 VRND------RNKKKKETSKQECTESYE-------------------------MTAE-------- 183

  Fly   399 LLPD--EILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVS-F 460
             |.|  |.:.|......|||.  ||.          .|...|..|.|          .:.|:. :
Human   184 -LDDLTEKIRKAHQETFPSLC--QLG----------KYTTNSSADHR----------VRLDLGLW 225

  Fly   461 RHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNR 525
            ...:|:....:..||||||.||.||.:...||||||||...::::||:..||....|::.|::..
Human   226 DKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGL 290

  Fly   526 SYTRDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAI-VIFSDRPGLEKAQLVEAIQSYY 589
            :..|.....||.....:.:..|..|:..:::|:.|..||:|| :|..||..||:...|:.:|...
Human   291 TLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPL 355

  Fly   590 IDTLRIYILNR-----HCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEI 649
            ::.|:|||..|     |        .:.|:|..:|:||::..:.||...:||:   ::|
Human   356 LEALKIYIRKRRPSKPH--------MFPKILMKITDLRSISAKGAERVITLKM---EIP------ 403

  Fly   650 WDVHAIPPSVQSHLQITQEENERLERAERMRASVGGAITAGIDCDSASTSAAAAAAQHQPQPQPQ 714
               .::||.:|          |.||.:|              ..:..:.|::...|:|.|...|
Human   404 ---GSMPPLIQ----------EMLENSE--------------GHEPLTPSSSGNTAEHSPSISP- 440

  Fly   715 PQPSSLTQNDSQHQTQPQLQ 734
                |..:|....|: |.:|
Human   441 ----SSVENSGVSQS-PLVQ 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	40/89 (45%)
		NR_LBD_EcR	420..652	CDD:132736	66/238 (28%)
RARB	NP_001277145.1	Modulating	1..87		26/122 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	47..78		8/55 (15%)
		NR_DBD_RAR	82..166	CDD:143522	41/90 (46%)
		Hinge	154..182		9/58 (16%)
		NR_LBD_RAR	186..416	CDD:132735	77/281 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..455		11/59 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157552
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840