DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment EcR and Nr1h3

DIOPT Version :9

Sequence 1:NP_001163061.1 Gene:EcR / 35540 FlyBaseID:FBgn0000546 Length:878 Species:Drosophila melanogaster
Sequence 2:NP_113815.2 Gene:Nr1h3 / 58852 RGDID:61909 Length:445 Species:Rattus norvegicus


Alignment Length:514 Identity:186/514 - (36%)
Similarity:260/514 - (50%) Gaps:91/514 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   147 NSTTPSTPTTPLHLQQNLGGAGGGGIGGMGILHHANGTPNGLIGVVGGGGGVGLGVGGGGVGGLG 211
            :|.|....|.|    |:.|..||...    ||......|...      ||.:.:|:.......| 
  Rat    15 DSATELWKTEP----QDAGDQGGNTC----ILREEARMPQST------GGALRIGLESSEPTAL- 64

  Fly   212 MQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPR-VQEELCLVCGDRASGYH 275
               .||::::...:    :|.|               :|.||||||: :..|||.||||:|||:|
  Rat    65 ---LPRAETLPEPT----ELRP---------------QKRKKGPAPKMLGNELCSVCGDKASGFH 107

  Fly   276 YNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQC 340
            ||.|:||||||||||||.|.|.|.|..|..|.||.|||||||||||:||...|||.|||:.|.|.
  Rat   108 YNVLSCEGCKGFFRRSVIKGARYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQI 172

  Fly   341 AMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPDEIL 405
            .:|:  .|.|:|:....||.|.:                        ...|||            
  Rat   173 RLKK--LKRQEEEQAQATSVSPR------------------------VSSPPQ------------ 199

  Fly   406 AKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQT----DVSFRHITEI 466
                  .:|.|:..||.:|.||:..|....:.|..|..|:...|...:.|:    ...|.|.||:
  Rat   200 ------VLPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPIAPDPQSREARQQRFAHFTEL 258

  Fly   467 TILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDS 531
            .|::||.||:|||.||.|.::.:||||.|||..:.|||:|..:|||:..|:||.|..:.||.|:.
  Rat   259 AIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNRED 323

  Fly   532 YKMAGM-ADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLR 594
            :..||: .:.|..:..|.|.|..:::::.|:|||.||.||| |||.::....||.:|..|::.|.
  Rat   324 FAKAGLQVEFINPIFEFSRSMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALH 388

  Fly   595 IYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVH 653
            .|:...|..|.:   .:.::|..|..||||.:.::|..|:|:|:::|||..|.||||||
  Rat   389 AYVSINHPHDRL---MFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVH 444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EcRNP_001163061.1 NR_DBD_EcR 261..351 CDD:143535 57/89 (64%)
NR_LBD_EcR 420..652 CDD:132736 90/237 (38%)
Nr1h3NP_113815.2 Transactivation AF-1, required for ligand-independent transactivation function. /evidence=ECO:0000250|UniProtKB:Q13133 1..94 26/115 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34 7/22 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 62..86 8/46 (17%)
NR_DBD_LXR 76..176 CDD:143534 64/114 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 178..200 9/63 (14%)
Transactivation AF-2, required for ligand-dependent transactivation function, mediates interaction with CCAR2. /evidence=ECO:0000250|UniProtKB:Q13133 203..445 94/245 (38%)
NR_LBD_LXR 208..443 CDD:132752 90/237 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166351544
Domainoid 1 1.000 130 1.000 Domainoid score I5071
eggNOG 1 0.900 - - E33208_3BAC4
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1137281at2759
OrthoFinder 1 1.000 - - FOG0005880
OrthoInspector 1 1.000 - - otm45595
orthoMCL 1 0.900 - - OOG6_108995
Panther 1 1.100 - - LDO PTHR24082
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X4275
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.750

Return to query results.
Submit another query.