DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EcR and Nr1h2

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_038944684.1	Gene:	Nr1h2 / 58851	RGDID:	61906	Length:	446	Species:	Rattus norvegicus

Alignment Length:	477	Identity:	168/477 - (35%)
Similarity:	243/477 - (50%)	Gaps:	77/477 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 GLGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSA--------NESCDAKKSKKGPAPR-VQEELC 264
            |.|......|.:..:|.....:..|.....|.|:        .|....:|.||||||: :..|||
  Rat    14 GNGSPQPSTSSTSPTIKEEGQETDPPPGSEGSSSAYIVVILEPEDEPERKRKKGPAPKMLGHELC 78

  Fly   265 LVCGDRASGYHYNALTCEGCKGFFRRSVTKSAV--YCCKFGRACEMDMYMRRKCQECRLKKCLAV 327
            .||||:|||:|||.|:||||||||||||.....  |.|:....|:||.:||||||.|||:||...
  Rat    79 RVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKEA 143

  Fly   328 GMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGN-------------GSLASGGGQDFV 379
            |||.:||:.|.|.    |:||.||::.:....|:....|:             .|..||.|:...
  Rat   144 GMREQCVLSEEQI----RKKKIQKQQQQQPPPPTEPASGSSARPAASPGTSEASSQGSGEGEGIQ 204

  Fly   380 KKEILDLMTCEPPQHATIPLLPDEILA---KCQARNI---PSLTYNQLAVIYKLIWYQDGYEQPS 438
            .....:||.             .:::|   :|..|:.   |.:|...|..            .|.
  Rat   205 LTAAQELMI-------------QQLVAAQLQCNKRSFSDQPKVTPWPLGA------------DPQ 244

  Fly   439 EEDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEV 503
            ..|.|:             ..|.|.||:.|::||.||:|||.:|.|.::.:||||.||||.:.|:
  Rat   245 SRDARQ-------------QRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEI 296

  Fly   504 MMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGM-ADNIEDLLHFCRQMFSMKVDNVEYALLTAI 567
            |:|..||||:|.::.|.|..:.:|::|.:..||: .:.|..:..|.|.|..:.:|:.|||||.||
  Rat   297 MLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAI 361

  Fly   568 VIFS-DRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEM 631
            .||| |||.:::...|||:|..|::.|..|...:...|.:.   :.::|..|..||||.:.::|.
  Rat   362 NIFSADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLR---FPRMLMKLVSLRTLSSVHSEQ 423

  Fly   632 CFSLKLKNRKLPKFLEEIWDVH 653
            .|:|:|:::|||..|.||||||
  Rat   424 VFALRLQDKKLPPLLSEIWDVH 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	52/91 (57%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	83/233 (36%)
Nr1h2	XP_038944684.1	NR_DBD_like	58..154	CDD:413390	54/95 (57%)
Nr1h2	XP_038944684.1	NR_LBD_LXR	209..444	CDD:132752	90/275 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351533
Domainoid	1	1.000	130	1.000	Domainoid score	I5071
eggNOG	1	0.900	-	-		E33208_3BAC4
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21397
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1137281at2759
OrthoFinder	1	1.000	-	-		FOG0005880
OrthoInspector	1	1.000	-	-		otm45595
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4275
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.850