DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EcR and vdrb

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001153457.1	Gene:	vdrb / 564511	ZFINID:	ZDB-GENE-080403-10	Length:	422	Species:	Danio rerio

Alignment Length:	412	Identity:	119/412 - (28%)
Similarity:	198/412 - (48%)	Gaps:	59/412 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 PRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRL 321
            ||:    |.||||:|:|:|:||:||||||||||||:.:.|.:.|.|..:|.:....||.||.|||
Zfish    20 PRI----CGVCGDKATGFHFNAMTCEGCKGFFRRSMKRKASFTCPFNGSCTITKDNRRHCQACRL 80

  Fly   322 KKCLAVGMRPECVVPENQCAMK------RREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVK 380
            |:||.:||..|.::.:.:...|      |::::|.:|..|...| ..|.....:|.....:.: .
Zfish    81 KRCLDIGMMKEFILTDEEVQRKKELIQRRKDEEAHREAQKPRLS-DEQRNIIDTLVDAHHKTY-D 143

  Fly   381 KEILDLMTCEPP-----------QHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGY 434
            ....|.....||           :.|::..|.|  .:.....:.|.....::.:...|:.||:
Zfish   144 DSYSDFSRFRPPVREGPVTRSASRAASLHSLSD--ASSDSFSHSPESGDRKMNLSNLLMMYQE-- 204

  Fly   435 EQPSEEDLRRIMSQPDENESQ-TDVS-FRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLK 497
                    :.:.|.||..|.. :.:| ..|:.::...::|.::.|||.:|.|.::..||||.|||
Zfish   205 --------QGLSSSPDSKEEDGSSLSMLPHLADLVSYSIQKVIGFAKMIPGFRELTAEDQIALLK 261

  Fly   498 ACSSEVMMLRMARRYDHSSDSIFFANNRSYT----------RDSYKMAGMADNIEDLLHFCRQMF 552
            :.:.||:|||        |:..|...:.|::          .|..|.....:.:|.|:.|...:.
Zfish   262 SSAIEVIMLR--------SNQSFSLEDMSWSCGGPEFKYCVNDVTKAGHTLELLEPLVKFQVGLK 318

  Fly   553 SMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLS 616
            .:.:...|:.||.||.:.| ||||::....|||:|....:.|:.||...|.|..:   .|||::.
Zfish   319 KLNLHEEEHVLLMAICLLSPDRPGVQDHVRVEALQDKVSEVLQAYIRAHHPGGRL---LYAKMIQ 380

  Fly   617 ILTELRTLGNQNAEMCFSLKLK 638
            .|.:||:|..::::...||..:
Zfish   381 KLADLRSLNEEHSKQYRSLSFQ 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	42/95 (44%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	63/232 (27%)
vdrb	NP_001153457.1	NR_DBD_VDR	15..121	CDD:143513	45/104 (43%)
		Hinge	96..125		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..128		5/22 (23%)
		NR_LBD	123..421	CDD:299703	73/305 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..190		7/46 (15%)
		Vitamin D3 binding. /evidence=ECO:0000250	224..234		1/9 (11%)
		Interaction with coactivator LXXLL motif. /evidence=ECO:0000250	243..261		8/17 (47%)
		Vitamin D3 binding. /evidence=ECO:0000250	268..275		4/14 (29%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P11473	411..419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593330
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940