DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EcR and nr1d4a

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_021325494.1	Gene:	nr1d4a / 563150	ZFINID:	ZDB-GENE-080403-5	Length:	572	Species:	Danio rerio

Alignment Length:	592	Identity:	144/592 - (24%)
Similarity:	215/592 - (36%)	Gaps:	179/592 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 GGVGLGVGGGGVGGLGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSANE---------------- 244
            |.|.|..|..|         ..|.|..|.|||....||||.....|..|
Zfish     8 GSVILYAGSSG---------SSSPSPGSPSSGYQTQSPSSHSQPSSPEEVTFTEIGAFKQQGNAG 63

  Fly   245 SCDAKK-----------SKKGPAPRVQEE----------------------LCLVCGDRASGYHY 276
            |.::.|           |..||.|.....                      ||.||||.|||:||
Zfish    64 SPNSPKLVFQFPEIYNNSTAGPNPHSYSHPIAGKRPCGFTGTFTKTGGMVLLCKVCGDIASGFHY 128

  Fly   277 NALTCEGCKGFFRRSVTKSAVY-CCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECV----VP 336
            ....|||||||||||:.::..| .|.....|.:....|.:||.||.||||:|||..:.|    :|
Zfish   129 GVHACEGCKGFFRRSIQQNINYKMCVKNENCLIMRMNRNRCQHCRFKKCLSVGMSRDAVRFGRIP 193

  Fly   337 ENQCAMKRREKKAQKEKDK-----------MTTSPS----------------------------- 361
                  ||.:::...|...           |.|||.
Zfish   194 ------KREKQRLLDEMQSYMNSLNESSMGMETSPQHEPPPSPIENQSKEAIGALSRAYQDIFTN 252

  Fly   362 -----SQHGGNGSLASGGGQDFVKKEILDLMTCEP--PQHAT----------IPLLPDEILAKCQ 409
                 ::..||.:::..........:..:.....|  ..|.|          .|:...|  :||.
Zfish   253 TQDHLNKRAGNNNISRSSSYQNSPSQDSNYPHANPLAGYHTTTHESFSGPVRCPVSTSE--SKCP 315

  Fly   410 ARNI--------PSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMS-QPDENESQTDVSFRHITE 465
            ...:        ||.:.|.         .|....|||:.......| ...:::|.....|:....
Zfish   316 VSLVDNNRYSYAPSFSQNH---------SQSSVNQPSQPTQAHYSSYTASQSQSPASCPFKLAAG 371

  Fly   466 ITIL-----------------------------TVQLIVEFAKGLPAFTKIPQEDQITLLKACSS 501
            ..:|                             .|:.:||||||:|.|.::.|.||:.||||.:.
Zfish   372 SKVLACPLNACPVSAPGVSSQQVWESFSQCFTPAVREVVEFAKGIPGFQELCQHDQVMLLKAGTF 436

  Fly   502 EVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTA 566
            :|:|:|....::|...|:.|.|.::|...:.:..||...::.:..|..::.|:.:::.|.||..|
Zfish   437 QVLMVRFCSLFNHKERSVTFLNGQTYPLGTLRGLGMGSLLDAMFEFSSKLSSLGLESDEMALFMA 501

  Fly   567 IVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAE 630
            :|:.| |..|:.....||.:|...|..||..|..||..|:.   .::|||..|.:||||.|.:::
Zfish   502 VVLVSADCSGISDMLAVEQLQEGLIRALRTLINRRHPDDNS---LFSKLLLRLPDLRTLNNLHSD 563

  Fly   631 MCFSLKL 637
            ...:.::
Zfish   564 KLLAFRI 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	41/116 (35%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	63/249 (25%)
nr1d4a	XP_021325494.1	NR_DBD_REV_ERB	111..199	CDD:143540	41/93 (44%)
nr1d4a	XP_021325494.1	NR_LBD	382..570	CDD:325017	55/190 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593365
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840