DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EcR and pparab

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001096037.1	Gene:	pparab / 557714	ZFINID:	ZDB-GENE-990415-211	Length:	459	Species:	Danio rerio

Alignment Length:	473	Identity:	123/473 - (26%)
Similarity:	191/473 - (40%)	Gaps:	104/473 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 GLGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPRVQEEL--------CL 265
            |.|.:.:...|::...|      ||||.:.|                .|..|:|.        |.
Zfish    56 GSGSESSTELDALTPAS------SPSSGVYG----------------CPVGQDEFTSTSLNLECR 98

  Fly   266 VCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMR 330
            ||.||||||||....||||||||||::.....| .|..|.|::....|.|||.||.:|||:|||.
Zfish    99 VCSDRASGYHYGVHACEGCKGFFRRTIRLKLEY-DKCERRCKIQKKNRNKCQYCRFQKCLSVGMS 162

  Fly   331 PECVVPENQCAMKRREKKAQKE----KDKMTTSPSSQHGGNGSLASGGGQDFVK---------KE 382
            ...:         |..:..|.|    |.::.|..........:||....:.:||         :.
Zfish   163 HNAI---------RFGRMPQSEKLRLKAEILTGERDVEDDQKTLAKQIYEAYVKNFNMNKSKART 218

  Fly   383 ILDLMTCEPP----QHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLR 443
            ||...|..||    ...|:.|.....:||...                              ...
Zfish   219 ILTGKTSTPPFVIHDMETLQLAEQTFVAKMMG------------------------------SCG 253

  Fly   444 RIMSQPDENESQTDVSFRHITEIT-ILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLR 507
            .::::..|      |...|..:.| :.||..:.||||.:|.|:.:...||:||||....|.:...
Zfish   254 GLLNKDPE------VRIFHCCQCTSVETVTELTEFAKSVPGFSNLDLNDQVTLLKYGVHEALFAM 312

  Fly   508 MARRYDHSSDSIFFANNRSY-TRDSYK--MAGMADNIEDLLHFCRQMFSMKVDNVEYAL-LTAIV 568
            :|...  :.|.:..|....: ||:..|  ....:|.:|....|..:..|:::|:.:.|| :.||:
Zfish   313 LASCM--NKDGLLVAYGSGFITREFLKSLRRPFSDMMEPKFQFAMKFNSLELDDSDLALFVAAII 375

  Fly   569 IFSDRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCF 633
            ...|||||.....:|.:|...::.|.:::.:.|.....   .:.|||..|.:||.|..::|::..
Zfish   376 CCGDRPGLVNVPHIERMQESIVNVLHLHLKSNHPDHGF---LFPKLLQKLVDLRQLVTEHAQLIQ 437

  Fly   634 SL-KLKNRKLPKFLEEIW 650
            .: |.::..|...|:||:
Zfish   438 EIKKTEDTSLHPLLQEIY 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	39/97 (40%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	56/237 (24%)
pparab	NP_001096037.1	NR_DBD_Ppar	96..179	CDD:143523	40/92 (43%)
		C4 zinc finger; ZnF_C4	97..161		35/64 (55%)
		NR_LBD_PPAR	193..458	CDD:132730	69/304 (23%)
		ligand binding domain of hormone receptors (HOLI)	279..429		43/154 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593367
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840