DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EcR and Hr96

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster

Alignment Length:	475	Identity:	119/475 - (25%)
Similarity:	186/475 - (39%)	Gaps:	126/475 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 CLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVG 328
            |.||||:|.||::||:|||.||.||||:......:.|.|.:.|::.:..||.||:|||:|||.:|
  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQKCRLRKCLDIG 71

  Fly   329 MRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILD-----LMT 388
            |:.|.::.|....:|||:.:..:.|.::      ...|..:..:.||::...|...|     |..
  Fly    72 MKSENIMSEEDKLIKRRKIETNRAKRRL------MENGTDACDADGGEERDHKAPADSSSSNLDH 130

  Fly   389 CEPPQHATIPLLPDEILAKCQAR--NIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDE 451
            ....|.:......|.....|..|  :.|....|.|             :..:|:.:.:|:|.||.
  Fly   131 YSGSQDSQSCGSADSGANGCSGRQASSPGTQVNPL-------------QMTAEKIVDQIVSDPDR 182

  Fly   452 NESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLL-KACSSEVMMLRMARRYDHS 515
            .....:...|                          .|::.|::: |..||:...||:.   .|.
  Fly   183 ASQAINRLMR--------------------------TQKEAISVMEKVISSQKDALRLV---SHL 218

  Fly   516 SDSIFFANNRSYTRDSYKMAG--MADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFSDRPGLEK 578
            .|         |..|:.|:..  |......|..|.:.| |...|.||  :::.||   |.|
  Fly   219 ID---------YPGDALKIISKFMNSPFNALTVFTKFM-SSPTDGVE--IISKIV---DSP---- 264

  Fly   579 AQLVEAIQSYY------IDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKL 637
            |.:||.:|:..      ||     |:|:.....      |:.|.||..:.:.|..||    :.:.
  Fly   265 ADVVEFMQNLMHSPEDAID-----IMNKFMNTP------AEALRILNRILSGGGANA----AQQT 314

  Fly   638 KNRKLPKFLEEIWDVHAIPPSVQSHLQITQEENERLERAERMRASVGGAITAGIDCDSASTS--- 699
            .:|| |...:|    .|:.|:..:            |||:.:..|:.|        :|...|
  Fly   315 ADRK-PLLDKE----PAVKPAAPA------------ERADTVIQSMLG--------NSPPISPHD 354

  Fly   700 AAAAAAQHQPQPQPQPQPSS 719
            ||.....|.|....||..||
  Fly   355 AAVDLQYHSPGVGEQPSTSS 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	39/86 (45%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	50/240 (21%)
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	40/90 (44%)
		NR_LBD	462..>573	CDD:299703
		NR_LBD_F1	523..702	CDD:132727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466837
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940