Protein Alignment EcR and nr1d2a

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001124064.2
• Gene: nr1d2a / 402815
• ZFINID: ZDB-GENE-040504-1
• Length: 504
• Species: Danio rerio
• Alignment Length: 499
• Identity: 129/499 - (25%)
• Similarity: 211/499 - (42%)
• Gaps: 125/499 - (25%)

  Fly   225 SSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPRVQEE--LCLVCGDRASGYHYNALTCEGCKGF 287
            :|...|||.|:.:..::...:.|...:.|....::...  ||.||||.|||:||....|||||||
Zfish    45 ASRATDLSISAGMLKHTRGHTSDKSLANKSSITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGF 109

  Fly   288 FRRSVTKSAVY--CCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECV----VPENQCAMKRRE 346
            ||||:.::..|  |.| ..:|.:....|.:||:||.||||:|||..:.|    :|       :||
Zfish   110 FRRSIQQNIQYKKCLK-TESCTIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIP-------KRE 166

  Fly   347 K-----KAQKEKDKMTTSPSSQH------GGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLL 400
            |     :.|...:.|..:...||      ..:.|.:|....|             .|:.:|..|:
Zfish   167 KQRMLLEMQTAMNNMMNNSQLQHMLHVSPSDSSSSSSASPPD-------------SPRSSTESLV 218

  Fly   401 PDEILAKCQARNIPSLTYNQLAVIYKLIWYQDG-------------------YEQPS-------- 438
            |.:..:.|.:.:                ..:||                   .|:|.
Zfish   219 PMDTASSCSSDS----------------GEEDGRFSYSASVSPAASETLSREEEEPQMQCWRRSD 267

  Fly   439 ---------EEDLRRIMSQPDENESQ-----------------------TDVS------FRHITE 465
                     |:..::.:..|.||.|.                       .|.|      :...:.
Zfish   268 CQNTTGPYREQTAQQCIRLPTENMSYCRRNMNEGGNRAHLVCPMSASPFVDASRPGHEVWEEFSR 332

  Fly   466 ITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRD 530
            ..|..|:.:|||||.:|.|.::.|.||:.||||.:.||:|:|....:|....::.|.:.|.|:.|
Zfish   333 SFIPAVREVVEFAKRIPGFQELSQHDQVNLLKAGTFEVLMVRFVPLFDVQQRTVSFMSGRRYSVD 397

  Fly   531 SYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLR 594
            ..:..|..:.:..:..|..::.::::::.|.:|.:|:|:.| ||..:|....|||:|...|..||
Zfish   398 LLRSMGAGELLNCMFEFSEKLAALQLNDEEMSLFSAVVLVSADRSAIEDVVGVEALQESLIRALR 462

  Fly   595 IYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLK 638
            ..|:..|..:|.   .:.|||..|.|||:|.|.::|...:.|::
Zfish   463 NLIMKNHSNESS---VFTKLLLKLPELRSLNNMHSEELLAFKIQ 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	43/102 (42%)
		NR_LBD_EcR	420..652	CDD:132736	67/285 (24%)
nr1d2a	NP_001124064.2	NR_DBD_REV_ERB	81..169	CDD:143540	43/95 (45%)
		NR_LBD	314..502	CDD:472173	57/190 (30%)