DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EcR and Nr1h5

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_006501686.1	Gene:	Nr1h5 / 381463	MGIID:	3026618	Length:	593	Species:	Mus musculus

Alignment Length:	493	Identity:	175/493 - (35%)
Similarity:	238/493 - (48%)	Gaps:	105/493 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 GGGVGGLGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSK--KGPAPRVQEELCLV 266
            ||...||..:.:.:|..|  :....:|..|.:        :.|.|..|.  ||.    .:.||:|
Mouse   162 GGSWCGLDARESGQSTYV--VVHDDEDEFPGA--------QRCRATCSLRWKGQ----DDMLCMV 212

  Fly   267 CGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRP 331
            |||:|||||||||||||||||||||:||:|||.||.|..|||||||||||||||||||.||||..
Mouse   213 CGDKASGYHYNALTCEGCKGFFRRSITKNAVYSCKNGGHCEMDMYMRRKCQECRLKKCKAVGMLA 277

  Fly   332 ECVVPENQCAMKRREKK----------AQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDL 386
            ||::.|.||..||..|.          .|.|.:...|...|     .|..||.|       :.|.
Mouse   278 ECLLTEIQCKSKRLRKNFKHGPALYPAIQVEDEGADTKHVS-----SSTRSGKG-------VQDN 330

  Fly   387 MTCEPPQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDE 451
            ||....:|.    |.:.|:...|...||      |....||:  |:|
Mouse   331 MTLTQEEHR----LLNTIVTVHQKSMIP------LGETSKLL--QEG------------------ 365

  Fly   452 NESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRY---D 513
              |..::||..::|:::|.:|.:::|.||||.|..:..|||..|.||..:|||.|.:|:.|   |
Mouse   366 --SNPELSFLRLSEVSVLHIQGLMKFTKGLPGFENLTTEDQAALQKASKTEVMFLHVAQLYGGKD 428

  Fly   514 HSS----------------------DSIFFANNRSYTRDSYKMAGMAD----NIEDLLHFCRQMF 552
            .:|                      :|:....|  :.::.|..|.:.|    .|..|.:|.|:|.
Mouse   429 STSGSTMRPAKPSAGTLEVHNPSADESVHSPEN--FLKEGYPSAPLTDITKEFIASLSYFYRRMS 491

  Fly   553 SMKVDNVEYALLTA-IVIFSDRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLS 616
            .:.|.:.||||||| .|:|||||.|:..|.:|.:|...:..|..:....|..|..   .:|.|:.
Mouse   492 ELHVSDTEYALLTATTVLFSDRPCLKNKQHIENLQEPVLQLLFKFSKMYHPEDPQ---HFAHLIG 553

  Fly   617 ILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVHA 654
            .|||||||.:.::|:....|.|:.:|.....|.||:|:
Mouse   554 RLTELRTLSHSHSEILRMWKTKDPRLVMLFSEKWDLHS 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	66/99 (67%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	77/261 (30%)
Nr1h5	XP_006501686.1	NR_DBD_FXR	207..290	CDD:143520	63/82 (77%)
Nr1h5	XP_006501686.1	NR_LBD_Fxr	335..585	CDD:132734	81/286 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847958
Domainoid	1	1.000	133	1.000	Domainoid score	I5038
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1137281at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.910