Protein Alignment EcR and nhr-283

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001370879.1
• Gene: nhr-283 / 3565118
• WormBaseID: WBGene00010186
• Length: 327
• Species: Caenorhabditis elegans
• Alignment Length: 419
• Identity: 87/419 - (20%)
• Similarity: 150/419 - (35%)
• Gaps: 126/419 - (30%)

  Fly   260 QEELCLVCGDR-ASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKK 323
            :|.:|.:|..| :||:.|..|.|..||.||||::....:..|:....|      .:||:.||.:|
 Worm     4 EESMCSICNVRESSGFSYGVLCCGACKMFFRRALFVKNIDTCRQKGEC------IKKCRYCRFQK 62

  Fly   324 CLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASG----GGQDFVKKEIL 384
            |:..||  .....||...:|                      .|.||::.    ..||.::|  .
 Worm    63 CIQAGM--SYTPTENLLELK----------------------NNDSLSAFIFNLAHQDELRK--Y 101

  Fly   385 DLMTCEPPQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQP 449
            .||.|......|:        |:....|.| |.:.:                           :|
 Worm   102 QLMNCRYDGDPTV--------AEIAEHNTP-LNFTK---------------------------KP 130

  Fly   450 DENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDH 514
            |:..       .::.|...:|         ||.:...:.:.:.:.:|.|.....::     :|..
 Worm   131 DDFP-------MNLGEWIFIT---------GLTSLNYLKKFNHVNMLNASDRHFLL-----KYSF 174

  Fly   515 SSDSIFFANNRSYTRDS-------------YKMAGMADNIEDLLHFCR---QMFSMKVDNVEYAL 563
            ...|||..:.|:..:..             .::.|:.....:.:. ||   ::..:||...|:.|
 Worm   175 FDMSIFTDSMRACEKGEGVITFPDGTEVIRAEVPGLEQKFLNGIR-CRLAARVNELKVTKEEFLL 238

  Fly   564 LTAIVIFSDRPGL----EKAQ-LVEAIQSYYIDTLRIYIL--NRHCGDSMSLVFYAKLLSILTEL 621
            |:|  :|...|||    |..: ::...|..|...|..|.|  .:..|.:.    :..|||:| ::
 Worm   239 LSA--VFFCNPGLPGISESGRGILSTYQKIYTSALLQYCLLTYQQTGPTR----FTDLLSVL-QV 296

  Fly   622 RTLGNQNAEMCFSLKLKNRKLPKFLEEIW 650
            .|...|:....|.|. ..|..|..|::|:
 Worm   297 VTKTRQDISYLFILN-SIRGPPSALKKIF 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	28/90 (31%)
		NR_LBD_EcR	420..652	CDD:132736	45/254 (18%)
nhr-283	NP_001370879.1	ZnF_C4	8..68	CDD:197701	22/65 (34%)
		HOLI	146..300	CDD:214658	33/166 (20%)