DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EcR and Nr1d2

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_035714.3	Gene:	Nr1d2 / 353187	MGIID:	2449205	Length:	576	Species:	Mus musculus

Alignment Length:	561	Identity:	145/561 - (25%)
Similarity:	227/561 - (40%)	Gaps:	173/561 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 DSVNSISSGRDDLSPSSSLNGYSANESCDAK-KSKKGPAPRVQEE------------LCLVCGDR 270
            :|.|..::|....:..||::|...::..|.. |:.|..||.:.:.            ||.||||.
Mouse    45 NSSNCDANGNPKNADISSIDGVLKSDRTDCPVKTGKTSAPGMTKSHSGMTKFSGMVLLCKVCGDV 109

  Fly   271 ASGYHYNALTCEGCKGFFRRSVTKSAVY--CCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPEC 333
            |||:||....|||||||||||:.::..|  |.| ...|.:....|.:||:||.||||:|||..:.
Mouse   110 ASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLK-NENCSIMRMNRNRCQQCRFKKCLSVGMSRDA 173

  Fly   334 V----VP---------ENQCAMK-----------------------------RREKKAQKEKDKM 356
            |    :|         |.|.|||                             :...|:|.|::.:
Mouse   174 VRFGRIPKREKQRMLIEMQSAMKTMMNTQFSGHLQNDTLAEQHDQSALPAQEQLRPKSQLEQENI 238

  Fly   357 TTSPSSQHGGNGSLASGGGQDFVKKEILDLMT-------------------CEPPQHA-TIPLLP 401
            ..:||               ||.|:|::.::|                   ..|||.. .||
Mouse   239 KNTPS---------------DFAKEEVIGMVTRAHKDTFLYNQEHRENSSESMPPQRGERIP--- 285

  Fly   402 DEILAKCQARNIPSLTYNQ-------------------LAVIYK---LIWYQDGYE--------- 435
                     ||:.....||                   |:..||   ::.|.:|:.
Mouse   286 ---------RNMEQYNLNQDHRGSGIHNHFPCSERQQHLSGQYKGRNIMHYPNGHAVCIANGHCM 341

  Fly   436 QPSEEDLRRIMSQ-PDENESQTD----------------------------VSFRHITEITILT- 470
            ..|....:|:..: |....|||:                            .|...|.|...::
Mouse   342 NFSSAYTQRVCDRIPVGGCSQTENRNSYLCNTGGRMHLVCPMSKSPYVDPQKSGHEIWEEFSMSF 406

  Fly   471 ---VQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSY 532
               |:.:|||||.:|.|..:.|.||:.||||.:.||:|:|.|..:|....::.|.:.:.|:.|..
Mouse   407 TPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDL 471

  Fly   533 KMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIY 596
            ...|..|.:..:..|..::.::::.:.|.:|.||:|:.| ||.|:|....|||:|...|..||..
Mouse   472 HSMGAGDLLSSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTL 536

  Fly   597 ILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKL 637
            |:..|..::.   .:.|||..|.:||:|.|.::|...:.|:
Mouse   537 IMKNHPNEAS---IFTKLLLKLPDLRSLNNMHSEELLAFKV 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	46/145 (32%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	71/283 (25%)
Nr1d2	NP_035714.3	Modulating	1..99		11/53 (21%)
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000269\|PubMed:29533925	1..60		3/14 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..90		11/44 (25%)
		NR_DBD_REV_ERB	98..186	CDD:143540	40/88 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..246		6/45 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..282		3/18 (17%)
		NR_LBD_REV_ERB	386..574	CDD:132738	58/190 (31%)
		Interaction with ZNHIT1. /evidence=ECO:0000250	394..576		59/184 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847969
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840