Protein Alignment EcR and thraa

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_571471.1
• Gene: thraa / 30670
• ZFINID: ZDB-GENE-990415-263
• Length: 427
• Species: Danio rerio
• Alignment Length: 434
• Identity: 133/434 - (30%)
• Similarity: 205/434 - (47%)
• Gaps: 78/434 - (17%)

  Fly   241 SANESCDAKKSKKGPAPRV--QEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKS--AVYCCK 301
            |.|.:.|...|..|..|..  ::|.|:||||:|:||||..:|||||||||||::.|:  ..|.||
Zfish    32 SMNSTSDKSISVPGYVPSYLEKDEPCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCK 96

  Fly   302 FGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGG 366
            :...|.:|...|.:||.||.:||::|||..:.|:.:::...|||..:..:||.|
Zfish    97 YDSCCIIDKITRNQCQLCRFRKCISVGMAMDLVLDDSKRVAKRRLIEENREKRK----------- 150

  Fly   367 NGSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLI--- 428
                         |:||:..:                       .|.|..|.::..:|..:.
Zfish   151 -------------KEEIVKTL-----------------------HNRPEPTVSEWELIRMVTEAH 179

  Fly   429 ---------WYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAF 484
                     |.|.....|  ||:.:..:...:|:.....:|...|:|....:..:|:|||.||.|
Zfish   180 RHTNAQGPHWKQKRKFLP--EDIGQSPAPTSDNDKVDLEAFSEFTKIITPAITRVVDFAKKLPMF 242

  Fly   485 TKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGM---ADNIEDLLH 546
            :::|.||||.|||.|..|:|.||.|.|||..|:::..:...:.:|:..|..|:   :|.|.||
Zfish   243 SELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLSGEMAVSREQLKNGGLGVVSDAIFDL-- 305

  Fly   547 FCRQMFSMKVDNVEYALLTAIVIF-SDRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVF 610
             .:.:....:|:.|.|||.|:::. |||.||...:.:|..|..|:.....||.:|....|.   |
Zfish   306 -GKSLSQFNLDDSEVALLQAVLLMSSDRSGLTCVEKIEKCQEMYLLAFEHYINHRKHNISH---F 366

  Fly   611 YAKLLSILTELRTLGNQNAEMCFSLKLK-NRKL--PKFLEEIWD 651
            :.|||..:|.||.:|..:|.....:|:: ..:|  |.|||...|
Zfish   367 WPKLLMKVTNLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	42/91 (46%)
		NR_LBD_EcR	420..652	CDD:132736	76/251 (30%)
thraa	NP_571471.1	Modulating	1..56		6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		3/7 (43%)
		NR_DBD_TR	56..142	CDD:143519	41/85 (48%)
		NR_LBD_TR	168..407	CDD:132733	74/246 (30%)