DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EcR and vdra

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_570994.1	Gene:	vdra / 30076	ZFINID:	ZDB-GENE-000210-31	Length:	453	Species:	Danio rerio

Alignment Length:	459	Identity:	132/459 - (28%)
Similarity:	214/459 - (46%)	Gaps:	78/459 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 LSPSSSLN--GYSANESCDAKKSKKGPAPRVQE-------------------ELCLVCGDRASGY 274
            |:.:|::|  |.|..|:...:.:..|.|..:.:                   .:|.||||:|:|:
Zfish     2 LTENSAVNSGGKSKCEAGACESTVNGDATSLMDLMAVSTSATGQDQFDRNAPPICGVCGDKATGF 66

  Fly   275 HYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQ 339
            |:||:||||||||||||:.:.|.:.|.|...|.:....||.||.||||:|:.:||..|.::.:.:
Zfish    67 HFNAMTCEGCKGFFRRSMKRKASFTCPFNGNCTITKDNRRHCQACRLKRCIDIGMMKEFILTDEE 131

  Fly   340 ------CAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPP------ 392
                  ..|||:|::|.:|..|...|.......| ||.....:.: .....|.:...||
Zfish   132 VQRKKDLIMKRKEEEAAREARKPRLSDEQMQIIN-SLVEAHHKTY-DDSYSDFVRFRPPVREGPV 194

  Fly   393 -----QHATIPLLPDEILAKCQARN-IPSLTYNQLAVIYKLIWYQD-GYEQPSEEDLRRIMSQPD 450
                 :.|::..|.|   |...:.| .|.....:|.....|:.||| |....||||.:..:|.
Zfish   195 TRSASRAASLHSLSD---ASSDSFNHSPESVDTKLNFSNLLMMYQDSGSPDSSEEDQQSRLSM-- 254

  Fly   451 ENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHS 515
                     ..|:.::...::|.::.|||.:|.|..:..||||.|||:.:.|::|||
Zfish   255 ---------LPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLR-------- 302

  Fly   516 SDSIFFANNRSYT----------RDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIF 570
            |:..|...:.|::          .|..|.....:.:|.|:.|...:..:|:...|:.||.||.:.
Zfish   303 SNQSFSLEDMSWSCGGPDFKYCINDVTKAGHTLELLEPLVKFQVGLKKLKLHEEEHVLLMAICLL 367

  Fly   571 S-DRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFS 634
            | ||||::....:||:|....|.|:.||..:|.|..:   .|||::..|.:||:|..::::...|
Zfish   368 SPDRPGVQDHVRIEALQDRLCDVLQAYIRIQHPGGRL---LYAKMIQKLADLRSLNEEHSKQYRS 429

  Fly   635 LKLK 638
            |..:
Zfish   430 LSFQ 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	43/114 (38%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	66/231 (29%)
vdra	NP_570994.1	NR_DBD_VDR	48..154	CDD:143513	44/105 (42%)
		Hinge	129..158		7/28 (25%)
		NR_LBD_VDR	156..452	CDD:132731	79/305 (26%)
		Vitamin D3 binding	255..265		1/9 (11%)
		Interaction with coactivator LXXLL motif	274..292		8/17 (47%)
		Vitamin D3 binding	299..306		4/14 (29%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P11473	442..450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5174
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010