Protein Alignment EcR and vdra

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_570994.1
• Gene: vdra / 30076
• ZFINID: ZDB-GENE-000210-31
• Length: 453
• Species: Danio rerio
• Alignment Length: 459
• Identity: 132/459 - (28%)
• Similarity: 214/459 - (46%)
• Gaps: 78/459 - (16%)

  Fly   231 LSPSSSLN--GYSANESCDAKKSKKGPAPRVQE-------------------ELCLVCGDRASGY 274
            |:.:|::|  |.|..|:...:.:..|.|..:.:                   .:|.||||:|:|:
Zfish     2 LTENSAVNSGGKSKCEAGACESTVNGDATSLMDLMAVSTSATGQDQFDRNAPPICGVCGDKATGF 66

  Fly   275 HYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQ 339
            |:||:||||||||||||:.:.|.:.|.|...|.:....||.||.||||:|:.:||..|.::.:.:
Zfish    67 HFNAMTCEGCKGFFRRSMKRKASFTCPFNGNCTITKDNRRHCQACRLKRCIDIGMMKEFILTDEE 131

  Fly   340 ------CAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPP------ 392
                  ..|||:|::|.:|..|...|.......| ||.....:.: .....|.:...||
Zfish   132 VQRKKDLIMKRKEEEAAREARKPRLSDEQMQIIN-SLVEAHHKTY-DDSYSDFVRFRPPVREGPV 194

  Fly   393 -----QHATIPLLPDEILAKCQARN-IPSLTYNQLAVIYKLIWYQD-GYEQPSEEDLRRIMSQPD 450
                 :.|::..|.|   |...:.| .|.....:|.....|:.||| |....||||.:..:|.
Zfish   195 TRSASRAASLHSLSD---ASSDSFNHSPESVDTKLNFSNLLMMYQDSGSPDSSEEDQQSRLSM-- 254

  Fly   451 ENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHS 515
                     ..|:.::...::|.::.|||.:|.|..:..||||.|||:.:.|::|||
Zfish   255 ---------LPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLR-------- 302

  Fly   516 SDSIFFANNRSYT----------RDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIF 570
            |:..|...:.|::          .|..|.....:.:|.|:.|...:..:|:...|:.||.||.:.
Zfish   303 SNQSFSLEDMSWSCGGPDFKYCINDVTKAGHTLELLEPLVKFQVGLKKLKLHEEEHVLLMAICLL 367

  Fly   571 S-DRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFS 634
            | ||||::....:||:|....|.|:.||..:|.|..:   .|||::..|.:||:|..::::...|
Zfish   368 SPDRPGVQDHVRIEALQDRLCDVLQAYIRIQHPGGRL---LYAKMIQKLADLRSLNEEHSKQYRS 429

  Fly   635 LKLK 638
            |..:
Zfish   430 LSFQ 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	43/114 (38%)
		NR_LBD_EcR	420..652	CDD:132736	66/231 (29%)
vdra	NP_570994.1	NR_DBD_VDR	48..154	CDD:143513	44/105 (42%)
		Hinge. /evidence=ECO:0000250|UniProtKB:P11473	129..158		7/28 (25%)
		NR_LBD_VDR	156..452	CDD:132731	79/305 (26%)
		Interaction with coactivator LXXLL motif. /evidence=ECO:0000250|UniProtKB:P13053	274..292		8/17 (47%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P11473	442..450