Protein Alignment EcR and Nr1d2

DIOPT Version :9

• Sequence 1: NP_001163061.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_671743.2
• Gene: Nr1d2 / 259241
• RGDID: 628828
• Length: 578
• Species: Rattus norvegicus
• Alignment Length: 556
• Identity: 147/556 - (26%)
• Similarity: 226/556 - (40%)
• Gaps: 161/556 - (28%)

  Fly   219 DSVNSISSGRDDLSPSSSLNGY--SANESCDAKKSKKGPAPRVQEE------------LCLVCGD 269
            :|.|..::|....:..||::|.  |....|..|..|.| ||.:.:.            ||.||||
  Rat    45 NSSNCDANGNPKNTDVSSIDGVLKSDRTDCPVKTGKPG-APGMTKSHSGMTKFSGMVLLCKVCGD 108

  Fly   270 RASGYHYNALTCEGCKGFFRRSVTKSAVY--CCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPE 332
            .|||:||....|||||||||||:.::..|  |.| ...|.:....|.:||:||.||||:|||..:
  Rat   109 VASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLK-NENCSIMRMNRNRCQQCRFKKCLSVGMSRD 172

  Fly   333 CV----VPENQCAMKRREKKAQ--KEKDKMTTSPSSQHGG---NGSLASGGGQ------------ 376
            .|    :|       :|||:..  :.:..|.|..|:|.||   :.:||....|
  Rat   173 AVRFGRIP-------KREKQRMLIEMQSAMKTMMSTQFGGHLQSDTLAEPHEQSVPPAQEQLRPK 230

  Fly   377 ---------------DFVKKEILDLMT-------------------CEPPQHA-TIPLLPDEILA 406
                           ||.|:|::.::|                   ..||... .||
  Rat   231 PQLEQENIKSTPPPSDFAKEEVIGMVTRAHKDTFLYNQEHRENSSESMPPHRGERIP-------- 287

  Fly   407 KCQARNIPSLTYN-------------------QLAVIYK---LIWYQDGYE---------QPSEE 440
                ||:.....|                   .|:..||   ::.|.:|:.         ..|..
  Rat   288 ----RNVEQYNLNHDHRGGGLHSHFPCSESQQHLSGQYKGRNMMHYPNGHTVCISNGHCVNFSSA 348

  Fly   441 DLRRIMSQ-PDENESQTD----------------------------VSFRHITEITILT----VQ 472
            ..:|:..: |....|||:                            .|...|.|...::    |:
  Rat   349 YPQRVCDRIPVGGCSQTESRNSYLCSTGGRMHLVCPMSKSPYVDPQKSGHEIWEEFSMSFTPAVK 413

  Fly   473 LIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGM 537
            .:|||||.:|.|..:.|.||:.||||.:.||:|:|.|..:|....::.|.:.:.|:.|.....|.
  Rat   414 EVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGA 478

  Fly   538 ADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYILNRH 601
            .|.:..:..|..::..:::.:.|.:|.||:|:.| ||.|:|....|||:|...|..||..|:..|
  Rat   479 GDLLSSMFEFSEKLNGLQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNH 543

  Fly   602 CGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKL 637
            ..::.   .:.|||..|.:||:|.|.::|...:.|:
  Rat   544 PNEAS---IFTKLLLKLPDLRSLNNMHSEELLAFKV 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	43/109 (39%)
		NR_LBD_EcR	420..652	CDD:132736	70/264 (27%)
Nr1d2	NP_671743.2	Modulating	1..99		13/54 (24%)
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000250|UniProtKB:Q60674	1..60		3/14 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..89		13/44 (30%)
		NR_DBD_REV_ERB	98..186	CDD:143540	43/95 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	214..247		1/32 (3%)
		NR_LBD_REV_ERB	388..576	CDD:132738	58/190 (31%)
		Interaction with ZNHIT1. /evidence=ECO:0000250	396..578		59/184 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351548
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840