DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EcR and Pparg

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_037256.1	Gene:	Pparg / 25664	RGDID:	3371	Length:	505	Species:	Rattus norvegicus

Alignment Length:	414	Identity:	114/414 - (27%)
Similarity:	179/414 - (43%)	Gaps:	78/414 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 CLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVY-CCKFGRACEMDMYMRRKCQECRLKKCLAV 327
            |.||||:|||:||....||||||||||::....:| .|...  |.:....|.|||.||.:|||||
  Rat   139 CRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLN--CRIHKKSRNKCQYCRFQKCLAV 201

  Fly   328 GMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPP 392
            ||....:         |..:..|.||:|:....||.            .|.:..|..||...  .
  Rat   202 GMSHNAI---------RFGRMPQAEKEKLLAEISSD------------IDQLNPESADLRAL--A 243

  Fly   393 QHATIPLLPDEILAKCQARNI--PSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQ 455
            :|.....:....|.|.:||.|  ...|.....|||               |:..:|...|:
  Rat   244 KHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIY---------------DMNSLMMGEDK---- 289

  Fly   456 TDVSFRHITEI------------------TILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSE 502
              :.|:|||.:                  ::..||.|.|:||.:|.|..:...||:||||....|
  Rat   290 --IKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHE 352

  Fly   503 VMMLRMARRYDHSSDSIFFANNRSY-TRDSYK--MAGMADNIEDLLHFCRQMFSMKVDNVEYALL 564
            ::...:|...  :.|.:..:..:.: ||:..|  .....|.:|....|..:..::::|:.:.|:.
  Rat   353 IIYTMLASLM--NKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIF 415

  Fly   565 TAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQN 628
            .|::|.| |||||...:.:|.||...:..|.:.:...|...|.   .:||:|..:|:||.:..::
  Rat   416 IAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQ---LFAKVLQKMTDLRQIVTEH 477

  Fly   629 AEMCFSLKL--KNRKLPKFLEEIW 650
            .::...:|.  .:..|...|:||:
  Rat   478 VQLLHVIKKTETDMSLHPLLQEIY 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	37/87 (43%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	60/255 (24%)
Pparg	NP_037256.1	PPARgamma_N	31..108	CDD:403692
		NR_DBD_Ppar	138..221	CDD:143523	40/92 (43%)
		Interaction with FAM120B. /evidence=ECO:0000250	205..280		21/112 (19%)
		NR_LBD_PPAR	237..504	CDD:132730	69/293 (24%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P37231	495..503		3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351546
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840