DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EcR and Nr1d1

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001106893.2	Gene:	Nr1d1 / 252917	RGDID:	628827	Length:	614	Species:	Rattus norvegicus

Alignment Length:	686	Identity:	158/686 - (23%)
Similarity:	240/686 - (34%)	Gaps:	218/686 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 TIIPINGNAN------GNGGSTNGQYVPGATNLGALANGMLNGGFNGMQQQIQN------GHGLI 146
            |.:..|.|..      |:.||:     |..|:..:|.:...||.|..:.|....      ...|.
  Rat     2 TTLDSNNNTGGVITYIGSSGSS-----PSRTSPESLYSDSSNGSFQSLTQGCPTYFPPSPTGSLT 61

  Fly   147 NSTTPSTPTTPLHLQQNLGGAGGGGIGGMGILHHANGTPNGLIGVVGGGGGVGLGVGGGGVGGLG 211
            .....|..|.|..|..:...:............: ||:|.|.:.|                   .
  Rat    62 QDPARSFGTVPPSLSDDSSPSSASSSSSSSSSFY-NGSPPGSLQV-------------------A 106

  Fly   212 MQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPRVQEELCLVCGDRASGYHY 276
            |:.:.|.    |.|.|..::   :.|||...                    ||.||||.|||:||
  Rat   107 MEDSSRV----SPSKGTSNI---TKLNGMVL--------------------LCKVCGDVASGFHY 144

  Fly   277 NALTCEGCKGFFRRSVTKSAVY--CCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECV----V 335
            ....|||||||||||:.::..|  |.| ...|.:....|.:||:||.||||:|||..:.|    :
  Rat   145 GVHACEGCKGFFRRSIQQNIQYKRCLK-NENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRI 208

  Fly   336 PENQCAMKRREKKAQKEKDK--------------MTTSPSSQHGGNGSLASG-----------GG 375
            |      ||.:::...|...              :.||| :.|..:||:...           |.
  Rat   209 P------KREKQRMLAEMQNAMNLANNQLSSLCPLETSP-APHPTSGSVGPSPPPAPAPTPLVGF 266

  Fly   376 QDFVKKEILDLMTCEPPQHATIPLLP------DEILAKCQARNIPSLTY---------------- 418
            ..|             ||..|.|..|      ::::::....:....||
  Rat   267 SQF-------------PQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGTSPGNFNANH 318

  Fly   419 -------------------------NQLAV---------------IYKLIW----YQDGYEQPSE 439
                                     |.||.               .|...|    ......||:.
  Rat   319 ASGSPPATTPQCWESQGCPSTPNDNNLLAAQRHNEALNGLRQGPSSYPPTWPSGPAHHSCHQPNS 383

  Fly   440 EDLR----RIMSQPDENESQTDV---------------------SFRHITEI-------TILTVQ 472
            ...|    .:.|.|:.......:                     |.|.:.||       ....|:
  Rat   384 NGHRLCPTHVYSAPEGKAPANGLRQGNTKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVR 448

  Fly   473 LIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGM 537
            .:|||||.:|.|..:.|.||:|||||.:.||:|:|.|..::....::.|.:..:|:.......||
  Rat   449 EVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGM 513

  Fly   538 ADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYILNRH 601
            .|.:..:..|..::.|:.:...|..|.||:|:.| ||.|:|.:..||.:|...:..||..:|...
  Rat   514 GDLLNAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNR 578

  Fly   602 CGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKL 637
            ..::..   :.|||..|.:||||.|.::|...|.::
  Rat   579 PSETSR---FTKLLLKLPDLRTLNNMHSEKLLSFRV 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	42/95 (44%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	68/270 (25%)
Nr1d1	NP_001106893.2	Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000250\|UniProtKB:Q3UV55	1..70		15/72 (21%)
		NR_DBD_REV_ERB	127..215	CDD:143540	43/114 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..286		13/65 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..336		0/24 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..384		4/27 (15%)
		NR_LBD	418..611	CDD:416257	59/195 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351560
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840