DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EcR and Vdr

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_058754.2	Gene:	Vdr / 24873	RGDID:	3959	Length:	423	Species:	Rattus norvegicus

Alignment Length:	480	Identity:	138/480 - (28%)
Similarity:	212/480 - (44%)	Gaps:	136/480 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 ESCDAKKSKKGP------APRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKF 302
            |:..|..|...|      .||:    |.||||||:|:|:||:||||||||||||:.:.|::.|.|
  Rat     2 EATAASTSLPDPGDFDRNVPRI----CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPF 62

  Fly   303 GRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPE------NQCAMKRREKKAQKEKDKMTTSPS 361
            ...|.:....||.||.||||:|:.:||..|.::.:      .:..|||:|::|.|:..:...|..
  Rat    63 NGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEE 127

  Fly   362 SQH------------------------------GGNGS------LASGGGQDFVKKEI----LDL 386
            .||                              |..||      |:..|.......::    ||:
  Rat   128 QQHIIAILLDAHHKTYDPTYADFRDFRPPVRVDGSTGSYSPRPTLSFSGNSSSSSSDLYTTSLDM 192

  Fly   387 MTCEPPQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDE 451
            |  ||...:.:.|..::       .:.||:|.                      ||..:...|
  Rat   193 M--EPSGFSNLDLNGED-------SDDPSVTL----------------------DLSPLSMLP-- 224

  Fly   452 NESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSS 516
                      |:.::...::|.::.|||.:|.|..:..:|||.|||:.:.||:|||
  Rat   225 ----------HLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLR--------- 270

  Fly   517 DSIFFANNRSYTRD---------SYK-------MAG-MADNIEDLLHFCRQMFSMKVDNVEYALL 564
                  :|:|:|.|         .||       .|| ..:.||.|:.|...:..:.:...|:.||
  Rat   271 ------SNQSFTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLL 329

  Fly   565 TAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQN 628
            .||.|.| ||||::.|:||||||....:||:.||..||.... |...|||::..|.:||:|..::
  Rat   330 MAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPG-SHQLYAKMIQKLADLRSLNEEH 393

  Fly   629 AEMCFSLKLK---NRKLPKFLEEIW 650
            ::...||..:   :.||...:.|::
  Rat   394 SKQYRSLSFQPENSMKLTPLVLEVF 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	44/95 (46%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	70/252 (28%)
Vdr	NP_058754.2	NR_DBD_VDR	16..122	CDD:143513	47/109 (43%)
		Hinge	90..126		7/35 (20%)
		NR_LBD_VDR	124..422	CDD:132731	87/354 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..180		5/20 (25%)
		Vitamin D3 binding	223..233		2/21 (10%)
		Interaction with coactivator LXXLL motif	242..260		7/17 (41%)
		Vitamin D3 binding	267..274		4/21 (19%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P11473	412..420		1/7 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351539
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940