Protein Alignment EcR and Rarb

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_017455067.1
• Gene: Rarb / 24706
• RGDID: 3535
• Length: 455
• Species: Rattus norvegicus
• Alignment Length: 579
• Identity: 155/579 - (26%)
• Similarity: 238/579 - (41%)
• Gaps: 172/579 - (29%)

  Fly   172 IGGMGI--LH--HANGTPNGLIGVVGGGGGVGLGVGGGGVGGLGMQHTPRSDSVNSISSGRDDL- 231
            |||:.:  ||  |.:..|:|.                         .||...::.:.|:..::|
  Rat    33 IGGLSLPPLHGLHGHPPPSGC-------------------------STPSPATIETQSTSSEELV 72

  Fly   232 -SPSSSLNGYSANESCDAKKSKKGPAPRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKS 295
             ||.|.|                 |.|||.:. |.||.|::|||||....|||||||||||:.|:
  Rat    73 PSPPSPL-----------------PPPRVYKP-CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKN 119

  Fly   296 AVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSP 360
            .:|.|...:.|.::...|.:||.|||:||..|||..|.|..:      |.:||.:..|.:.|.|.
  Rat   120 MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRND------RNKKKKEPSKQECTESY 178

  Fly   361 SSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPD--EILAKCQARNIPSLTYNQLAV 423
            .                         ||.|         |.|  |.:.|......|||.  ||.
  Rat   179 E-------------------------MTAE---------LDDLTEKIRKAHQETFPSLC--QLG- 206

  Fly   424 IYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVS-FRHITEITILTVQLIVEFAKGLPAFTKI 487
                     .|...|..|.|          .:.|:. :...:|:....:..||||||.||.||.:
  Rat   207 ---------KYTTNSSADHR----------VRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGL 252

  Fly   488 PQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMF 552
            ...||||||||...::::||:..||....|::.|::..:..|.....||.....:.:..|..|:.
  Rat   253 TIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLL 317

  Fly   553 SMKVDNVEYALLTAI-VIFSDRPGLEKAQLVEAIQSYYIDTLRIYILNR-----HCGDSMSLVFY 611
            .:::|:.|..||:|| :|..||..||:...|:.:|...::.|:|||..|     |        .:
  Rat   318 PLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPH--------MF 374

  Fly   612 AKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVHAIPPSVQSHLQITQEENERLERA 676
            .|:|..:|:||::..:.||...:||:   ::|         .::||.:|          |.||.:
  Rat   375 PKILMKITDLRSISAKGAERVITLKM---EIP---------GSMPPLIQ----------EMLENS 417

  Fly   677 ERMRASVGGAITAGIDCDSASTSAAAAAAQHQPQPQPQP-QPSSLTQNDSQHQTQPQLQ 734
            |              ..:..:.:::...|:|.|...|.. :.|.::|:       |.||
  Rat   418 E--------------GHEPLTPNSSGNTAEHSPSVSPSSVETSGVSQS-------PLLQ 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	40/89 (45%)
		NR_LBD_EcR	420..652	CDD:132736	66/238 (28%)
Rarb	XP_017455067.1	NR_DBD_RAR	82..166	CDD:143522	41/90 (46%)
		NR_LBD_RAR	186..416	CDD:132735	77/281 (27%)