DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EcR and Vdr

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_033530.2	Gene:	Vdr / 22337	MGIID:	103076	Length:	422	Species:	Mus musculus

Alignment Length:	450	Identity:	137/450 - (30%)
Similarity:	211/450 - (46%)	Gaps:	77/450 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 ESCDAKKSKKGP------APRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKF 302
            |:..|..|...|      .||:    |.||||||:|:|:||:||||||||||||:.:.|::.|.|
Mouse     2 EAMAASTSLPDPGDFDRNVPRI----CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPF 62

  Fly   303 GRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPE------NQCAMKRREKKAQKEKDKMTTSPS 361
            ...|.:....||.||.||||:|:.:||..|.::.:      .:..|||:|::|.|:..:...|..
Mouse    63 NGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEE 127

  Fly   362 SQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPL-----LPDEILAKCQARN----IPSLT 417
            .||  ..::..............|.....||..|.:..     .|....:...:.|    .|||.
Mouse   128 QQH--IIAILLDAHHKTYDPTYADFRDFRPPIRADVSTGSYSPRPTLSFSGDSSSNSDLYTPSLD 190

  Fly   418 YNQLAVIYKLIWYQDGYEQPSEE-DLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGL 481
            ..:.|....:...::|.:.||.. ||..:...|            |:.::...::|.::.|||.:
Mouse   191 MMEPASFSTMDLNEEGSDDPSVTLDLSPLSMLP------------HLADLVSYSIQKVIGFAKMI 243

  Fly   482 PAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRD---------SYK---- 533
            |.|..:..:|||.|||:.:.||:|||               :|:|:|.|         .||
Mouse   244 PGFRDLTSDDQIVLLKSSAIEVIMLR---------------SNQSFTLDDMSWDCGSQDYKYDIT 293

  Fly   534 ---MAG-MADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTL 593
               .|| ..:.||.|:.|...:..:.:...|:.||.||.|.| ||||::.|:||||||....:||
Mouse   294 DVSRAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTL 358

  Fly   594 RIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLK---NRKLPKFLEEIW 650
            :.||..||.... |...|||::..|.:||:|..::::...||..:   :.||...:.|::
Mouse   359 QTYIRCRHPPPG-SHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVF 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	44/95 (46%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	74/252 (29%)
Vdr	NP_033530.2	NR_DBD_VDR	16..122	CDD:143513	47/109 (43%)
		Hinge	97..126		6/28 (21%)
		NR_LBD_VDR	124..421	CDD:132731	86/323 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..185		2/23 (9%)
		Vitamin D3 binding. /evidence=ECO:0000250	222..232		2/21 (10%)
		Interaction with coactivator LXXLL motif. /evidence=ECO:0000250	241..259		7/17 (41%)
		Vitamin D3 binding. /evidence=ECO:0000250	266..273		4/21 (19%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P11473	411..419		1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847960
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940