Protein Alignment EcR and Nr1h2

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_033499.1
• Gene: Nr1h2 / 22260
• MGIID: 1352463
• Length: 446
• Species: Mus musculus
• Alignment Length: 473
• Identity: 168/473 - (35%)
• Similarity: 250/473 - (52%)
• Gaps: 65/473 - (13%)

  Fly   207 VGGLGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSA--------NESCDAKKSKKGPAPR-VQEE 262
            |.|.|......|.:..:|.....:..|.....|.|:        .|....:|.||||||: :..|
Mouse    12 VPGNGSPQPSTSATSPTIKEEGQETDPPPGSEGSSSAYIVVILEPEDEPERKRKKGPAPKMLGHE 76

  Fly   263 LCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAV--YCCKFGRACEMDMYMRRKCQECRLKKCL 325
            ||.||||:|||:|||.|:||||||||||||.....  |.|:....|:||.:||||||.|||:||.
Mouse    77 LCRVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCK 141

  Fly   326 AVGMRPECVVPENQCAMKRREKKAQKE----KDKMTTS---PSSQHGGNGSLASGGGQDFVKKEI 383
            ..|||.:||:.|.|...||.:|:.|::    .:...:|   |::..|.:.:.:.|.|:.    |.
Mouse   142 EAGMREQCVLSEEQIRKKRIQKQQQQQPPPPSEPAASSSGRPAASPGTSEASSQGSGEG----EG 202

  Fly   384 LDLMTCEPPQHATIPLLPDEILA---KCQARNI---PSLTYNQLAVIYKLIWYQDGYEQPSEEDL 442
            :.|...:       .|:..:::|   :|..|:.   |.:|...|..            .|...|.
Mouse   203 IQLTAAQ-------ELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGA------------DPQSRDA 248

  Fly   443 RRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLR 507
            |:             ..|.|.||:.|::||.||:|||.:|.|.::.:||||.||||.:.|:|:|.
Mouse   249 RQ-------------QRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLE 300

  Fly   508 MARRYDHSSDSIFFANNRSYTRDSYKMAGM-ADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS 571
            .||||:|.::.|.|..:.:|::|.:..||: .:.|..:..|.|.|..:.:|:.|||||.||.|||
Mouse   301 TARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFS 365

  Fly   572 -DRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSL 635
             |||.:::...|||:|..|::.|..|...:...|.:.   :.::|..|..||||.:.::|..|:|
Mouse   366 ADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLR---FPRMLMKLVSLRTLSSVHSEQVFAL 427

  Fly   636 KLKNRKLPKFLEEIWDVH 653
            :|:::|||..|.||||||
Mouse   428 RLQDKKLPPLLSEIWDVH 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	52/91 (57%)
		NR_LBD_EcR	420..652	CDD:132736	83/233 (36%)
Nr1h2	NP_033499.1	Transactivation AF-1, required for ligand-independent transactivation function. /evidence=ECO:0000250|UniProtKB:P55055	1..76		16/63 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..69		13/56 (23%)
		NR_DBD_like	58..154	CDD:413390	54/95 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..201		9/45 (20%)
		Transactivation AF-2, required for ligand-dependent transactivation function, mediates interaction with CCAR2. /evidence=ECO:0000250|UniProtKB:P55055	205..446		93/276 (34%)
		NR_LBD_LXR	209..444	CDD:132752	89/269 (33%)