Protein Alignment EcR and Rarb

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001276689.1
• Gene: Rarb / 218772
• MGIID: 97857
• Length: 482
• Species: Mus musculus
• Alignment Length: 603
• Identity: 162/603 - (26%)
• Similarity: 239/603 - (39%)
• Gaps: 173/603 - (28%)

  Fly   143 HGLINSTTPSTPTTPLHLQQNLGGAGGGGIGGMGILHHANGTPNGLIGVVGGGGGVGLGVGGGGV 207
            |||.....||..:||  ...::|.|.....||.........||:
Mouse    42 HGLHGHPPPSGCSTP--SPASVGQACQRTTGGSQFAASTKWTPS--------------------- 83

  Fly   208 GGLGMQHTPRSDSVNSISSGRDDL--SPSSSLNGYSANESCDAKKSKKGPAPRVQEELCLVCGDR 270
                     .:.::.:.|:..::|  ||.|.|                 |.|||.:. |.||.|:
Mouse    84 ---------LNAAIETQSTSSEELVPSPPSPL-----------------PPPRVYKP-CFVCQDK 121

  Fly   271 ASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVV 335
            :|||||....|||||||||||:.|:.:|.|...:.|.::...|.:||.|||:||..|||..|.|.
Mouse   122 SSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVR 186

  Fly   336 PENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLL 400
            .:      |.:||.:..|.:.|.|..                         ||.|         |
Mouse   187 ND------RNKKKKEPSKQECTESYE-------------------------MTAE---------L 211

  Fly   401 PD--EILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVS-FRH 462
            .|  |.:.|......|||.  ||.          .|...|..|.|          .:.|:. :..
Mouse   212 DDLTEKIRKAHQETFPSLC--QLG----------KYTTNSSADHR----------VRLDLGLWDK 254

  Fly   463 ITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSY 527
            .:|:....:..||||||.||.||.:...||||||||...::::||:..||....|::.|::..:.
Mouse   255 FSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTL 319

  Fly   528 TRDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAI-VIFSDRPGLEKAQLVEAIQSYYID 591
            .|.....||.....:.:..|..|:..:::|:.|..||:|| :|..||..||:...|:.:|...::
Mouse   320 NRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLE 384

  Fly   592 TLRIYILNR-----HCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWD 651
            .|:|||..|     |        .:.|:|..:|:||::..:.||...:||:   ::|
Mouse   385 ALKIYIRKRRPSKPH--------MFPKILMKITDLRSISAKGAERVITLKM---EIP-------- 430

  Fly   652 VHAIPPSVQSHLQITQEENERLERAERMRASVGGAITAGIDCDSASTSAAAAAAQHQPQPQPQPQ 716
             .::||.:|..|       |..|..|.:..|..|.|                 |:|.|...|
Mouse   431 -GSMPPLIQEML-------ENSEGHEPLTPSSSGNI-----------------AEHSPSVSP--- 467

  Fly   717 PSSLTQNDSQHQTQPQLQ 734
              |..:|....|: |.||
Mouse   468 --SSVENSGVSQS-PLLQ 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	40/89 (45%)
		NR_LBD_EcR	420..652	CDD:132736	66/238 (28%)
Rarb	NP_001276689.1	Modulating	1..114		23/120 (19%)
		NR_DBD_RAR	109..193	CDD:143522	41/90 (46%)
		Hinge	181..209		9/58 (16%)
		NR_LBD_RAR	213..443	CDD:132735	76/278 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..482		13/61 (21%)