DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment EcR and Nr1d1

DIOPT Version :9

Sequence 1:NP_001163061.1 Gene:EcR / 35540 FlyBaseID:FBgn0000546 Length:878 Species:Drosophila melanogaster
Sequence 2:NP_663409.2 Gene:Nr1d1 / 217166 MGIID:2444210 Length:615 Species:Mus musculus


Alignment Length:575 Identity:146/575 - (25%)
Similarity:215/575 - (37%) Gaps:181/575 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   219 DSVNSISSG----RDDLSPSSSLNGYSANESCDAKKSKKGPAPRVQEE----------------- 262
            |...|..|.    .||.||||:.:..|::.|.....|..|......|:                 
Mouse    63 DPARSFGSAPPSLSDDSSPSSASSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKGTSNITKLN 127

  Fly   263 ----LCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVY--CCKFGRACEMDMYMRRKCQECRL 321
                ||.||||.|||:||....|||||||||||:.::..|  |.| ...|.:....|.:||:||.
Mouse   128 GMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLK-NENCSIVRINRNRCQQCRF 191

  Fly   322 KKCLAVGMRPECV----VPENQCAMKRREKKAQKEKDK--------------MTTSPSSQHGGNG 368
            ||||:|||..:.|    :|      ||.:::...|...              :.||| :.|..:|
Mouse   192 KKCLSVGMSRDAVRFGRIP------KREKQRMLAEMQSAMNLANNQLSSLCPLETSP-TPHPTSG 249

  Fly   369 SLASG-----------GGQDFVKKEILDLMTCEPPQHATIPLLP------DEILAKC-------- 408
            |:...           |...|             ||..|.|..|      ::::::.        
Mouse   250 SMGPSPPPAPAPTPLVGFSQF-------------PQQLTPPRSPSPEPTMEDVISQVARAHREIF 301

  Fly   409 -----------------QARNIPSLT----------------YNQLAV---------------IY 425
                             .|...||.|                .|.||.               .|
Mouse   302 TYAHDKLGTSPGNFNANHASGSPSATTPHRWESQGCPSAPNDNNLLAAQRHNEALNGLRQGPSSY 366

  Fly   426 KLIW----YQDGYEQPSEEDLR----RIMSQPDENESQTDVSFRHITEITIL------------- 469
            ...|    ......||:....|    .:.|.| |.|:..:...:..|:..:|             
Mouse   367 PPTWPSGPTHHSCHQPNSNGHRLCPTHVYSAP-EGEAPANSLRQGNTKNVLLACPMNMYPHGRSG 430

  Fly   470 -TVQLI---------------VEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDS 518
             |||.|               |||||.:|.|..:.|.||:|||||.:.||:|:|.|..::....:
Mouse   431 RTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQT 495

  Fly   519 IFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLV 582
            :.|.:..:|:.......||.|.:..:..|..::.|:.:...|..|.||:|:.| ||.|:|.:..|
Mouse   496 VMFLSRTTYSLQELGAMGMGDLLNAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASV 560

  Fly   583 EAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKL 637
            |.:|...:..||..:|.....::..   :.|||..|.:||||.|.::|...|.::
Mouse   561 EQLQETLLRALRALVLKNRPSETSR---FTKLLLKLPDLRTLNNMHSEKLLSFRV 612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EcRNP_001163061.1 NR_DBD_EcR 261..351 CDD:143535 43/116 (37%)
NR_LBD_EcR 420..652 CDD:132736 71/271 (26%)
Nr1d1NP_663409.2 Modulating 1..129 14/65 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..120 14/56 (25%)
Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000269|PubMed:30792350 1..70 2/6 (33%)
Crucial for activation of GJA1 49..285 70/242 (29%)
NR_DBD_REV_ERB 128..216 CDD:143540 42/94 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..286 13/64 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 312..337 4/24 (17%)
NR_LBD 419..612 CDD:299703 58/195 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847981
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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