DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EcR and Rora

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_038674.1	Gene:	Rora / 19883	MGIID:	104661	Length:	523	Species:	Mus musculus

Alignment Length:	498	Identity:	130/498 - (26%)
Similarity:	213/498 - (42%)	Gaps:	90/498 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 GGVGGLGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPRVQEELCLVCGD 269
            |.....|.:.||.:.     .:||...:|.:......|:.|.....:||....:::...|.:|||
Mouse    19 GSEAAAGSRETPLTQ-----DTGRKSEAPGAGRRQSYASSSRGISVTKKTHTSQIEIIPCKICGD 78

  Fly   270 RASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECV 334
            ::||.||..:||||||||||||...:|.|.|...:.|.:|...|.:||.|||:|||||||..:.|
Mouse    79 KSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAV 143

  Fly   335 ----------------VPENQCAMKRREKKAQK-EKDKMTTSPSSQHGG------------NGSL 370
                            |.:::...::|:.:.|. |.:.:|.:.:....|            :|..
Mouse   144 KFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSTYMDGHT 208

  Fly   371 ASGGGQD-FVKKEILDLMTCEPPQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGY 434
            ..|...| .|....||:..........|..:..|          |...|...:..:....:.:|.
Mouse   209 PEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPE----------PICDYTPASGFFPYCSFTNGE 263

  Fly   435 EQPS------------------------EEDLRRI-----MSQPDEN--ESQTDVSFR----HIT 464
            ..|:                        .|:|::|     :.:..||  ..|.:|.::    .||
Mouse   264 TSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKIT 328

  Fly   465 EITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTR 529
            |    .:|.:|||||.:..|.::.|.|||.||||.|.||:.:||.|.:|..:::::| :.:..:.
Mouse   329 E----AIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYF-DGKYASP 388

  Fly   530 DSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTL 593
            |.:|..|..|.|..:..|.:.:.||.:...|.||.:|.|:.| ||..|::...:|.:|......|
Mouse   389 DVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLAL 453

  Fly   594 RIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLK 636
            :..:...|..|.:    ..||:..::.||.|..::.|...:.|
Mouse   454 QHVLQKNHREDGI----LTKLICKVSTLRALCGRHTEKLMAFK 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	41/105 (39%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	64/253 (25%)
Rora	NP_038674.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		10/48 (21%)
		NR_DBD_ROR	66..160	CDD:143526	39/93 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..183		4/28 (14%)
		NR_LBD_ROR_like	272..511	CDD:132737	62/230 (27%)
		AF-2	506..511
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840