Protein Alignment EcR and nhr-212

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001122995.1
• Gene: nhr-212 / 187964
• WormBaseID: WBGene00020153
• Length: 405
• Species: Caenorhabditis elegans
• Alignment Length: 449
• Identity: 93/449 - (20%)
• Similarity: 175/449 - (38%)
• Gaps: 96/449 - (21%)

  Fly   257 PRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSV-TKSA--VYCCKFGRACEMDMYMRRKCQE 318
            |...:.||.:|...|.|.|:.|::|..|..|||||: .|:|  ..|.:....||:.:..:..|::
 Worm     2 PDTSQILCQICALPAHGNHFGAVSCRACSAFFRRSILEKNAENFKCLRGNNTCEVKLAGKFYCKK 66

  Fly   319 CRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEI 383
            ||||:|...||.|:|:             ..|.::||:  .|..                :.|.:
 Worm    67 CRLKRCYETGMDPKCL-------------DFQLDRDKI--KPRQ----------------IPKTV 100

  Fly   384 LDL-------MTCEPPQHATIPLLPDEILAKCQARNI----PSLTYNQLAVIYKLIW---YQDGY 434
            ..|       :.|.||:|.:...:.|......:|.|.    |.:....|.::.|:..   :.|.:
 Worm   101 ATLVGRPSYIVHCAPPEHNSKKGILDVSYLIVKAHNCLDFPPQMFNKNLTILEKMQCANEFLDSF 165

  Fly   435 EQ-PSEEDLRRI--MSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLL 496
            |. .:.|.|.:|  |..|..|:.    .|.|..|:..|.....:.|..|   |..:|:..|:.:|
 Worm   166 ENLTNSEMLTKIPMMQYPVINKQ----FFLHFWELDFLKTAKWLSFLDG---FYSLPRGVQMQIL 223

  Fly   497 KAC---------SSEVMMLRMARRYDHSSDSIFFANNR-----------SYTRD--SYKMAGMAD 539
            .:.         .|:...||.:.  |...:....:.|.           |:..|  :.::....:
 Worm   224 MSTWHLRARLHRLSQTAKLRKSE--DIGKNDFMMSKNSCLDLKTCQLDVSWCTDYPNEQIQFFLE 286

  Fly   540 NIEDLLHFCRQMFSMKVD----NVEYALLTAIVIFSDRPGLEKAQLVEAIQSYYIDTLRIYILNR 600
            |.:|.:|  .::..:.|:    .:|...:|....|......|:..::..::. |:|.:. ..|:|
 Worm   287 NSDDWVH--NEVVDLIVELNPSEIEMTFMTCQFCFHYAGKREQGHILSVMEK-YLDLIS-NDLHR 347

  Fly   601 HCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVHAIPPSV 659
            :..|. .:..|.:.   :|::..:.|...::.:..:.|.....||  :|:.:|...|.:
 Worm   348 YYQDK-GIRNYTER---VTKMMKINNWLQKIIWEKRWKRELAEKF--DIFHLHFSHPEM 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	29/92 (32%)
		NR_LBD_EcR	420..652	CDD:132736	47/263 (18%)
nhr-212	NP_001122995.1	ZnF_C4	8..80	CDD:197701	27/71 (38%)
		Hormone_recep	178..375	CDD:459675	36/213 (17%)