Protein Alignment EcR and nhr-125

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_504194.2
• Gene: nhr-125 / 187520
• WormBaseID: WBGene00003715
• Length: 399
• Species: Caenorhabditis elegans
• Alignment Length: 493
• Identity: 103/493 - (20%)
• Similarity: 160/493 - (32%)
• Gaps: 186/493 - (37%)

  Fly   264 CLVCGDRASGYHYNALTCEGCKGFFRRSVTK--SAVYCCKFGRACEMDMYMRRKCQECRLKKCLA 326
            |.:|..:|.|.|:..|||..|..||||:...  |.:.|.|.|  |.     |..|:.||||||..
 Worm    13 CRICNQKAHGNHFGVLTCRACASFFRRAAFSKWSQLKCQKGG--CS-----RNFCKRCRLKKCRE 70

  Fly   327 VGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEP 391
            :||               ...|.|..:|....:...|.....||||     ||.:..|.|. |:.
 Worm    71 MGM---------------DTTKFQYNRDSFRATGQFQLPPPRSLAS-----FVGRPELFLF-CDT 114

  Fly   392 PQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQT 456
            .......|:....|.:...|.|     ||            |||.|:        |..::.|:.|
 Worm   115 EAPNAKMLIDVRYLLEEAGRII-----NQ------------GYETPA--------SGKNQLENLT 154

  Fly   457 DVSFRHIT---------------------EITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACS 500
            : .|::|.                     |....||...:.:.:|   |.|:....||||::
 Worm   155 E-GFKYIKVDMNNISSSKYASKDAIISMWEYYFFTVTRWLMYFEG---FQKLNSHTQITLIQ--- 212

  Fly   501 SEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEY---- 561
                             |::                   |:...||       ..|..|:|
 Worm   213 -----------------SVW-------------------NVWSRLH-------KYVATVDYHKAN 234

  Fly   562 --ALLTAIVIFSDRPGLEKAQLVEA-IQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRT 623
              .|.|.:||.:....:|..:.... :..|.::.:|.|:..:||.:          ..||..||.
 Worm   235 PDTLPTNVVIHNTLVDIENVEFDSTWLSDYPVEHVRRYLSVQHCRE----------FDILGTLRK 289

  Fly   624 LGNQN-------AEMCFS----------LKLKNRKLPKFLEEIWDVHA----------------- 654
            |....       |::||.          :|:..:.|.....::.|.:.
 Worm   290 LNPSELEITYLFAQICFEHAGKRNQGDIMKVTEQFLDSLANDLHDYYVNEMNNSRYFLRLTQLLK 354

  Fly   655 ---------IPPSVQSHLQITQEENERLERAERMRASV 683
                     |.|..|....|.::|.|:||:.::.:.|:
 Worm   355 INQAIQFSDISPQKQIRNNIIKKEAEKLEKLQKSQFSI 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	29/88 (33%)
		NR_LBD_EcR	420..652	CDD:132736	47/276 (17%)
nhr-125	NP_504194.2	ZnF_C4	13..74	CDD:197701	28/82 (34%)
		Hormone_recep	164..360	CDD:459675	38/254 (15%)