Protein Alignment EcR and nhr-123

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_503207.2
• Gene: nhr-123 / 187411
• WormBaseID: WBGene00003713
• Length: 412
• Species: Caenorhabditis elegans
• Alignment Length: 430
• Identity: 88/430 - (20%)
• Similarity: 158/430 - (36%)
• Gaps: 70/430 - (16%)

  Fly   257 PRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRL 321
            |::..:.|.:|.:.|.|.|:.|:||..|..||||.........||....|.........|::||:
 Worm    18 PKISPKKCQICENPAHGKHFGAITCRACAAFFRRFGISKKFKPCKLENKCTFRKNGYFSCKKCRM 82

  Fly   322 KKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPS----SQHGGNGSLASGGGQDFVKKE 382
            ::||..||..:....:.: .:.|::.:..:..|..:..||    |...|:.|........|:..:
 Worm    83 QRCLQFGMTIDNFQFDRE-PIYRKDLEIPQTVDTFSGRPSLILFSAPSGSSSSKHYLDVQFLVDK 146

  Fly   383 ILDLMTCEPPQHATIPLLPDEILAKCQ--ARNIPSLTYNQLAVIYKL-------IWYQDGYEQPS 438
            .::::.    ..:..||....:|.|..  .|||.........||.|:       ||
 Worm   147 AIEVLL----NGSETPLQVPNVLQKLAIGLRNIRGPKEKTSKVITKVGREEVFGIW--------- 198

  Fly   439 EEDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGL-PAFTKIPQEDQITLLKA---- 498
            |||:.|           |.....:..:...|...:.:|..||: ..|:::  |:..|..:|
 Worm   199 EEDMLR-----------TAKWLTYFDDFQRLPNSVQIEILKGVWSLFSRL--ENLATTARARKRK 250

  Fly   499 -CSSEVMMLRMARRY---DHSSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMFSMKVDNV 559
             |..:::|..|.:..   |..:..:..:....||.:..|.....|.:..|....:.|..::..|.
 Worm   251 LCKDDLVMSYMNKNLVISDLKTIEVDLSWCSKYTYEQLKFFDQYDGVRQLDSLIKAMLDLQPTNE 315

  Fly   560 EYALLTAIVIFSD------RPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSIL 618
            |...:...:.|..      .|.||   .:|.:|....:.|..|.:|.......|:.. |.::.|
 Worm   316 ELCYMICQLCFHQVGKQLHGPILE---TIEKLQEVLSNHLHDYYVNHLIQPKYSMRI-ASMMKI- 375

  Fly   619 TELRTLGNQNAEMC-FSLKLKNRKLPKFLEEIWDVHAIPP 657
                   |...:.| :..::|...:..|  |::.|....|
 Worm   376 -------NNTVDQCPYRDRVKGELMRVF--EVFHVECSHP 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	24/89 (27%)
		NR_LBD_EcR	420..652	CDD:132736	47/254 (19%)
nhr-123	NP_503207.2	ZnF_C4	24..93	CDD:197701	23/68 (34%)
		Hormone_recep	179..379	CDD:459675	43/233 (18%)