Protein Alignment EcR and nhr-195

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001256111.1
• Gene: nhr-195 / 186625
• WormBaseID: WBGene00019115
• Length: 404
• Species: Caenorhabditis elegans
• Alignment Length: 491
• Identity: 103/491 - (20%)
• Similarity: 183/491 - (37%)
• Gaps: 154/491 - (31%)

  Fly   242 ANESCDAK------KSKKGPAPRVQEELCLVCGDRASGYHYNALTCEGCKGFFRR-SVTKSAVYC 299
            |:.|.|.|      ||:|          |.||..||.|.||..::|..|..|||| .:|....:.
 Worm     3 ASTSADVKTKKSLRKSRK----------CQVCYLRAHGNHYGVVSCRACAAFFRRVFITHKQHFK 57

  Fly   300 CKFGR-ACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCA---MKRREKKAQKEKDKMTTSP 360
            |:.|: .||.:...|..|:.||.|||..:||||:.:    ||:   :...|......||  |:||
 Worm    58 CQGGQMKCEPNSVGRWDCKSCRTKKCFDIGMRPDNI----QCSDDTISYSESIPNDPKD--TSSP 116

  Fly   361 SSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPDEILAKCQARNIPSLTYNQLAVIY 425
            |:        .|...::::  ...|.         |..|...|.:.|.|   |.:...||.: :.
 Worm   117 SA--------ISSSSEEYI--TFFDF---------TSLLESIENILKTQ---IDTPITNQTS-LQ 158

  Fly   426 KLIWYQDGYEQPSEEDLRRIMSQPDEN--------ESQTDVSFRHITE--ITILTVQLIVEFAKG 480
            ||.:        ..:::|:  ||..||        :::|..|::...|  .|.||.
 Worm   159 KLAY--------GLKEIRK--SQVLENIPVVTSIGKNETFNSWKMDMERAATWLTY--------- 204

  Fly   481 LPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNIEDLL 545
            ...|..:..|:::.:.|.      |..:.||.:.|          :.|.|..:
 Worm   205 FDEFCTLKSEEKMLITKC------MWLLFRRLERS----------AMTADLRR------------ 241

  Fly   546 HFCRQMFSMKVDNVEYALLTAIVIFSDRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVF 610
                   :.|....|||:.|..::     .:|.....:.:..:..:.:::::      .|.|.::
 Worm   242 -------AKKCQKSEYAMKTDSLV-----SMETKYEFDWLSHFSAEQIKVFL------GSSSGMY 288

  Fly   611 YAKLLSILTELRTLGNQNAEMCFSL------------------------KLKNRKLPKFLEEIWD 651
            ..:|.:.:.|::.   .:.|:||.:                        |:.:..|..:..|...
 Worm   289 CEELTNCIMEVQP---SDEELCFIICDLCFQYLGIKVGGEIQQKLEGLQKILSDNLHNYYLERNR 350

  Fly   652 VHAIPPSVQSHLQITQEENERLERAERMRASVGGAI 687
            .|.....:...::|:|:.|:.:|  |:.|..|.|.:
 Worm   351 EHRYTYRLSQLMKISQQYNKLME--EKRRVGVVGEV 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	33/94 (35%)
		NR_LBD_EcR	420..652	CDD:132736	39/265 (15%)
nhr-195	NP_001256111.1	ZnF_C4	20..91	CDD:197701	30/80 (38%)
		Hormone_recep	174..364	CDD:459675	34/247 (14%)