Protein Alignment EcR and nhr-186

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_504063.1
• Gene: nhr-186 / 185909
• WormBaseID: WBGene00018541
• Length: 370
• Species: Caenorhabditis elegans
• Alignment Length: 471
• Identity: 108/471 - (22%)
• Similarity: 161/471 - (34%)
• Gaps: 158/471 - (33%)

  Fly   241 SANESCDAKKSKKGPAPRVQE-------ELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVY 298
            |||.|.|:..|...|.....|       |.|.|||..|..|:|..|:|..||.||||.......|
 Worm     2 SANPSPDSCGSDYLPTDMEPETSAVSVSEKCAVCGKPAFCYNYGVLSCNACKMFFRRVEVDHITY 66

  Fly   299 CCKFGRAC-EMDMY-----MRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKD-KM 356
            .||:...| :...|     :..:|:.||.::|:.:|||        ..|..:.:.:...:.| |:
 Worm    67 NCKYWNTCYDGQEYVDANNVSTRCRACRYRRCIDLGMR--------YIAPGKPDLELVNQVDGKL 123

  Fly   357 TTSPSSQHGGNGSLASGGGQDFV------KKEILDLMTCEPPQHATIPLLPDEILAKCQARNIPS 415
            .|..               |:.|      ..:||:..|.|.|
 Worm   124 NTLL---------------QELVLMDARRSHKILNFYTSENP----------------------- 150

  Fly   416 LTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKG 480
             |..|:..              ..:..|.::.:..:..        :|.|.:.||:.:.||....
 Worm   151 -TLRQMVT--------------RSKGSRMVLKKATQEV--------NIHEWSFLTIYVSVEMFLN 192

  Fly   481 LPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNIEDLL 545
            |.....|..||:|.||:..|.:.::|..|.|      :|....:|..|.|.      .|...|.|
 Worm   193 LDFMQNIDNEDKIVLLREFSLKTLVLNSAMR------AILNKTDRVMTPDG------KDVYPDRL 245

  Fly   546 HFCRQMFS-----------------MKVDNVEYALLTAIVI-------FSDRPGLEKAQLVEAIQ 586
               .||||                 :||.:.|:.||..|:.       .||    |..:.:.|.|
 Worm   246 ---LQMFSLDFLNNIRSRLATRFRELKVSSEEHMLLNLILFCNSALHPLSD----ETKKTLSARQ 303

  Fly   587 SYYIDTLRIYILN--RHCGDSMSLVFYAKLLSI----------LTELRTLGNQNAEMCFSLKLKN 639
            ..|...|....|:  :..|.|.    :|.||||          :|.|.:|        |.|::..
 Worm   304 KVYSSALLQLCLSTYQQTGPSR----FADLLSICHVVNKTVEDVTYLTSL--------FKLQMPF 356

  Fly   640 RKLPKFLEEIWDVHAI 655
            .:..|...::  ||.|
 Worm   357 IEYKKLFVDV--VHLI 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	30/102 (29%)
		NR_LBD_EcR	420..652	CDD:132736	57/267 (21%)
nhr-186	NP_504063.1	ZnF_C4	31..>80	CDD:197701	19/48 (40%)
		HOLI	179..339	CDD:214658	47/182 (26%)