Protein Alignment EcR and nhr-172

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_504933.2
• Gene: nhr-172 / 183808
• WormBaseID: WBGene00016927
• Length: 311
• Species: Caenorhabditis elegans
• Alignment Length: 365
• Identity: 79/365 - (21%)
• Similarity: 135/365 - (36%)
• Gaps: 103/365 - (28%)

  Fly   287 FFRRSVTKSAVYCCKFGRAC-EMDMYMRR-KCQECRLKKCLAVGMRPECVVPENQCAMKRREKKA 349
            ||||::.::..:.||....| |:...... ||..||.|:||.:||:   :.|.|...::...:||
 Worm     2 FFRRAIVENPFFNCKKLNNCYEVSTNSNHLKCAACRFKRCLQLGMK---LPPSNNAILELENQKA 63

  Fly   350 QKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPDEILAKCQARNIP 414
            .|.|..:          ||.:            :.|...||  :|.|.           ..|:.|
 Worm    64 HKLKKLL----------NGLI------------LRDAKRCE--RHLTF-----------YTRSDP 93

  Fly   415 SLTYNQLAVIYKLIWYQDGYEQPSEEDL---RRIMSQPDENESQTDVSFRHITEITILTVQLIVE 476
            ||                       ||:   ::.|:. |:||:.. .||    |.:.|.|..::|
 Worm    94 SL-----------------------EDILINKKTMNN-DKNENAV-TSF----EWSFLAVFNVIE 129

  Fly   477 FAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNI 541
            :.........:...|:..|.:..:....:|..|.|        .|...||........|.:.|.|
 Worm   130 YFSTFDFIENLEYSDKKLLFQCNTFNANVLCGAMR--------GFKEKRSKMVTPTGQAILPDGI 186

  Fly   542 EDLLHFCRQM------------FSMKVDNVEYALLTAIVIFS-DRPGLEKAQL-VEAIQSYYIDT 592
            ..||:...||            ..:|:.|.|:.||..|.... |....|.|:: :.:.|:::.:.
 Worm   187 APLLNTTSQMLHRVSCQVIAIIIELKMTNEEFILLNLIFFLRIDNNLSESAKISLASHQNFFTNA 251

  Fly   593 LRIYILNRHCGDSMSLVFYAKLLSIL-------TELRTLG 625
            |..|...::  :..:...:|.|||:.       :|::.:|
 Worm   252 LFEYCQLKY--ERRAPSRFADLLSLCQIIQKTSSEMKYIG 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	21/65 (32%)
		NR_LBD_EcR	420..652	CDD:132736	45/230 (20%)
nhr-172	NP_504933.2	ZnF_C4	<1..47	CDD:197701	16/44 (36%)
		HOLI	120..281	CDD:214658	34/170 (20%)