Protein Alignment EcR and nhr-167

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_510004.1
• Gene: nhr-167 / 183613
• WormBaseID: WBGene00008208
• Length: 343
• Species: Caenorhabditis elegans
• Alignment Length: 372
• Identity: 81/372 - (21%)
• Similarity: 146/372 - (39%)
• Gaps: 87/372 - (23%)

  Fly   264 CLVCGDRASGYHYNALTCEGCKGFFRRSVTKSA-VYCCKFGRAC-EMDMYMRRKCQECRLKKCLA 326
            |.|||...:.::|:.|:|..||.||||.:.::. :..|..|..| |...|: .||..||.:|||.
 Worm     8 CAVCGRFTTEFNYSVLSCNSCKIFFRRLIVRTVPIKKCFRGERCFEKTPYI-FKCTSCRFQKCLY 71

  Fly   327 VGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEP 391
            |||    .:|.....:::     .||:....|....::..|..:.|          :.:....|.
 Worm    72 VGM----TLPSYLLVLEQ-----NKEQRLAITIDCVRNTHNKRMDS----------LFNFFVTEM 117

  Fly   392 PQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQT 456
            ..:.      |:|:      .:..:||.:                 .:|.:|.        :.||
 Worm   118 NPNV------DDIV------ELNKITYTK-----------------RDEHIRM--------DFQT 145

  Fly   457 DVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEV-MMLRMARRYDHSSDSIF 520
            ......:|.|         :|.|..|....:...||:.|||....:: .::...|.|......|.
 Worm   146 WAFHSCVTTI---------DFMKQFPFVNLLRSTDQMILLKESYVKLGALISATRAYSSKKQCIS 201

  Fly   521 FANNRS-YTRDSYKMAGMADNIEDLLHFCR---QMFSMKVDNVEYALLTAIVIFSDRPGL----E 577
            |.:... ..:..:.:..::.|:|:.:. ||   ::..:.:.|.|:.|| ::::|.: |.:    |
 Worm   202 FPDGTDCLPKTQWTVPKISPNLENRIR-CRVIDKLRELNIQNDEFYLL-SVLLFCN-PAITNLSE 263

  Fly   578 KAQ-LVEAIQSYYIDTLRIYIL--NRHCGDSMSLVFYAKLLSILTEL 621
            ..| |:.:.|..|...|..|.|  .:..|.|.    :::||.:.|.|
 Worm   264 NGQLLLTSYQKMYSSALLYYCLLTYQKSGPSR----FSELLGLFTLL 306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	29/88 (33%)
		NR_LBD_EcR	420..652	CDD:132736	42/214 (20%)
nhr-167	NP_510004.1	ZnF_C4	7..75	CDD:197701	28/71 (39%)
		HOLI	147..306	CDD:214658	37/174 (21%)