Protein Alignment EcR and nhr-166

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_494682.1
• Gene: nhr-166 / 183605
• WormBaseID: WBGene00016772
• Length: 363
• Species: Caenorhabditis elegans
• Alignment Length: 409
• Identity: 104/409 - (25%)
• Similarity: 162/409 - (39%)
• Gaps: 98/409 - (23%)

  Fly   264 CLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRAC-EMDMYMRRKCQECRLKKCLAV 327
            |.:|.:::||.||..|:|:.||.||:|:......|.|:...:| .|| ...|||:.||.||||.|
 Worm    11 CAICRNKSSGCHYGVLSCDACKMFFKRTYLMEKYYTCRRQESCYNMD-GGNRKCKACRFKKCLEV 74

  Fly   328 GMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPP 392
            ||.||..              ::.|...::|:..:|      |.:   ||....|.|..:
 Worm    75 GMNPELF--------------SRSESQIISTNIPTQ------LIT---QDHRNAEFLQKL----- 111

  Fly   393 QHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTD 457
                      :||.|.:..            ::|:|   |.||.||..||.|..|:........:
 Worm   112 ----------KILDKTRHE------------VFKII---DTYENPSFVDLVRQESRLSCYLRPKN 151

  Fly   458 VSFRHITEITI-----LTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMA-RRYDHSS 516
            :|:.: ||..:     |.:.|.||..|.|..:.|:...|:|.||:..:.:...|.:| ..:....
 Worm   152 ISWEN-TERKLKPWGSLGMLLAVETIKSLDFYPKLLLSDRILLLETVTLKSFHLSVAFDSFSQKK 215

  Fly   517 DSIFFANNRSYTRDSY-KMAGMADNIEDLLHF-CRQMFSMKVDNVEYALLTAIVIFSDRPGLEKA 579
            :.|...:......||. ||....|.|..||.. .:.:.:||:...||.||..|||.:..
 Worm   216 EKILAPDGSEMFPDSLNKMDFCKDLIMRLLTTPVKPLIAMKLTETEYLLLGIIVICNPE------ 274

  Fly   580 QLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNA------EMCFSLKLK 638
                      ||.|      ...|.::...|..|.:::|.:...:.|..:      |:....::.
 Worm   275 ----------IDGL------SPSGKAIITAFLQKTINVLLQFCLINNPRSAPSRLLEIISINQIL 323

  Fly   639 NR------KLPKFLEEIWD 651
            ||      ||...|.:.||
 Worm   324 NRQFHASYKLFDALRKQWD 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	32/87 (37%)
		NR_LBD_EcR	420..652	CDD:132736	61/252 (24%)
nhr-166	NP_494682.1	NR_DBD_HNF4A	11..86	CDD:143518	32/89 (36%)
		HOLI	165..326	CDD:214658	41/182 (23%)