Protein Alignment EcR and Nr1i2

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_035066.1
• Gene: Nr1i2 / 18171
• MGIID: 1337040
• Length: 431
• Species: Mus musculus
• Alignment Length: 449
• Identity: 118/449 - (26%)
• Similarity: 203/449 - (45%)
• Gaps: 81/449 - (18%)

  Fly   246 CDAKKSKKGPAPRVQEE-----LCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGR- 304
            |:...|.......|:||     :|.||||:|:|||:|.:|||||||||||::.::....|.|.:
Mouse    15 CEEADSALEEPINVEEEDGGLQICRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFRKG 79

  Fly   305 ACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGS 369
            .||:....||:||.|||:|||..||:.|.:: .:....:||....:|:::|:...|.   ||.|.
Mouse    80 TCEITRKTRRQCQACRLRKCLESGMKKEMIM-SDAAVEQRRALIKRKKREKIEAPPP---GGQGL 140

  Fly   370 LASGGGQDFVKKEILDLMT----------------------CEPPQHATIPLLPDEIL-AKCQAR 411
            ...   |..:.:|::|...                      ||.|:.....||.|... ::....
Mouse   141 TEE---QQALIQELMDAQMQTFDTTFSHFKDFRLPAVFHSGCELPEFLQASLLEDPATWSQIMKD 202

  Fly   412 NIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVE 476
            .:|.....||......||   .|:.||:.|.:.|:.           ...|:.:::....:.::.
Mouse   203 RVPMKISLQLRGEDGSIW---NYQPPSKSDGKEIIP-----------LLPHLADVSTYMFKGVIN 253

  Fly   477 FAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNI 541
            |||.:..|..:|.||||:|||..:.|:.:||....:|..:             .:::...:|...
Mouse   254 FAKVISYFRDLPIEDQISLLKGATFEMCILRFNTMFDTET-------------GTWECGRLAYCF 305

  Fly   542 ED------------LLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTL 593
            ||            |:.|...:..:::...||.|:.||.:|| ||||:.:..:|:.:|..:..||
Mouse   306 EDPNGGFQKLLLDPLMKFHCMLKKLQLHKEEYVLMQAISLFSPDRPGVVQRSVVDQLQERFALTL 370

  Fly   594 RIYILNRHCGDSMSL--VFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIW 650
            :.||   .|......  ..:.|::::|||||::..|..:....::..:......::|::
Mouse   371 KAYI---ECSRPYPAHRFLFLKIMAVLTELRSINAQQTQQLLRIQDSHPFATPLMQELF 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	42/95 (44%)
		NR_LBD_EcR	420..652	CDD:132736	57/246 (23%)
Nr1i2	NP_035066.1	NR_DBD_like	37..124	CDD:413390	40/87 (46%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	63..89		6/25 (24%)
		Hinge	105..142		9/40 (23%)
		NR_LBD	140..425	CDD:472173	66/317 (21%)