Protein Alignment EcR and nhr-28

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001024388.1
• Gene: nhr-28 / 181705
• WormBaseID: WBGene00003624
• Length: 437
• Species: Caenorhabditis elegans
• Alignment Length: 475
• Identity: 105/475 - (22%)
• Similarity: 176/475 - (37%)
• Gaps: 125/475 - (26%)

  Fly   254 GPAPRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQE 318
            |.:|      |.|||:...|.|:.|..|..|..||||||..:..|.|:....|.:...:|..|:.
 Worm     4 GKSP------CSVCGEAGDGAHFGAEACRACAAFFRRSVALNKAYVCRAMGTCVIQKNVRCMCRA 62

  Fly   319 CRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEI 383
            ||..||:|||||...|       .:.||..|.:|    |:|.||.:
 Worm    63 CRFTKCIAVGMRKSAV-------QRHRELFASQE----TSSESSSN------------------- 97

  Fly   384 LDLMTCEPPQHATIPLLPDEILAKCQARNIPSLT-----YNQLAVIYKLIWYQDGYEQPSEEDLR 443
                   |....|:....|......:...:|:|:     |||::.:.::|....|.......:.:
 Worm    98 -------PRISPTLSWPMDISPQSYEETGMPTLSQLNENYNQMSTVRRVIHNTGGDNIFHRREPK 155

  Fly   444 RIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRM 508
            .:        :.||....|:.||.::...:|    |..|.|.::.||.:..|.:......|:|..
 Worm   156 AV--------AYTDAHNVHLKEIGLVADWII----KSYPDFEQLHQEQKKLLYRNFFLPFMILEC 208

  Fly   509 ARR--YDHSSDSIFFAN------NRSYT-------------RDSYKMAGMA-----DNIEDLLHF 547
            ...  .::.:|.:|..:      ||..|             .::.:|.|.:     .|:.|
 Worm   209 GYMCCLNNRTDILFLPSGDYIDCNRPETFYGHRIKSHLISPNEAVRMFGPSFEIYRRNVLD---- 269

  Fly   548 CRQMFSMKVDNVEYALLTAIVIFSDRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYA 612
              .|....|||.|:..|.::|::..  ||| .|..|.:|....:..||.        ...|.:|.
 Worm   270 --PMRRENVDNFEFFTLCSLVLWDH--GLE-GQTEECVQMARCNRERIL--------REVLYYYR 321

  Fly   613 KLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEE-----IWDVHAIPPSV---------QSHL 663
            ::..|......|.|    :...|....|.:.:|.|:     :::|:::..:.         .|..
 Worm   322 RVKQISDPSMRLAN----LLVLLPALQRSVRRFQEDVEITHVFNVYSVEETFYELVSGRLSDSFF 382

  Fly   664 QITQ----EENERLERAERM 679
            |.||    .|.|::.:.|.:
 Worm   383 QTTQLTTSVEEEKVIKTEEI 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	33/89 (37%)
		NR_LBD_EcR	420..652	CDD:132736	50/262 (19%)
nhr-28	NP_001024388.1	ZnF_C4	7..76	CDD:197701	30/74 (41%)
		HOLI	168..345	CDD:214658	41/201 (20%)