Protein Alignment EcR and nhr-55

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_503215.2
• Gene: nhr-55 / 178570
• WormBaseID: WBGene00003645
• Length: 424
• Species: Caenorhabditis elegans
• Alignment Length: 441
• Identity: 86/441 - (19%)
• Similarity: 165/441 - (37%)
• Gaps: 107/441 - (24%)

  Fly   232 SPSSSLNGYSANESCDAKKSKKGPAPRV--QEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTK 294
            |||||.:..|::.|         |:..|  ..:.|.|||.::.|.|:.|:||..|..||||..:.
 Worm     3 SPSSSSSFCSSSSS---------PSSLVLYSPDTCQVCGQKSHGKHFGAVTCRACAAFFRRCGSA 58

  Fly   295 SAVYCCKFGRACEMDMYMRR---KCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKM 356
            :....|:....||   :::.   .|:.||||||..|||..|....:......::.|.|.:.....
 Worm    59 NNFKPCRRNMNCE---FLKNGWFNCKPCRLKKCQDVGMTIENFQFDRDSFSPKKAKIALENFHNQ 120

  Fly   357 TTSPSSQHGGNGSLASGGGQDFVKKEILDLMT---CEPPQHATIPLLPDEI--LAKCQARNIPSL 416
            .....:...|..:|.           ::...|   |.|..:..:..|.|::  :.| :...:|..
 Worm   121 VPFSIATFTGRSNLI-----------VISAPTEEECIPKCYIDVQFLIDKLSNVLK-EGPEVPLH 173

  Fly   417 TYN-----------------QLAVIYKL-------IWYQDGYEQPSEEDLRRIMSQPDENESQTD 457
            |.|                 :|.:|.||       :|         ::|:.::...
 Worm   174 TPNALEKLALGLQIIRGRKRELKLITKLGKEETLGLW---------QDDMMKVAKW--------- 220

  Fly   458 VSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFA 522
              ..:..:...|:.::..|..||:   .|:....:...|.|....:|:.:......|:......|
 Worm   221 --LTYFDDFQQLSHRMRSEMLKGM---WKVWSRLETLALTAMGRRLMICQKDMIMTHTEKEQVMA 280

  Fly   523 NNRS----------YTRDSYKM---AGMADNIEDLLHFCRQMFSMKVDNVE--YALLTAIVIFSD 572
            :.:.          ||.:..:.   :.:.|..|.::   :.|..::..:||  |.:..|.:.::.
 Worm   281 HPKQIEVDISWCSRYTLEQLRFFADSDLDDRNEQVI---QAMMELQPTDVELSYMMCQACLHYAG 342

  Fly   573 R--PGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTEL 621
            :  .| |..::.|..|....:.|..|.:||     |::..|:..::.|.::
 Worm   343 KRYQG-EVLEIAERFQETLSNHLHDYYVNR-----MNMPQYSMRVANLMKI 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	30/92 (33%)
		NR_LBD_EcR	420..652	CDD:132736	36/226 (16%)
nhr-55	NP_503215.2	ZnF_C4	27..96	CDD:197701	27/71 (38%)
		Hormone_recep	192..395	CDD:459675	36/228 (16%)