Protein Alignment EcR and nhr-6

DIOPT Version :9

• Sequence 1: NP_001163061.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_497731.1
• Gene: nhr-6 / 175462
• WormBaseID: WBGene00003605
• Length: 619
• Species: Caenorhabditis elegans
• Alignment Length: 665
• Identity: 148/665 - (22%)
• Similarity: 232/665 - (34%)
• Gaps: 240/665 - (36%)

  Fly    14 LPEESSSEVTSSSNGLVLPSGVNMS----PSSLD----SHDYCDQDLWL--CGNESGSFGGSNGH 68
            :|||...:.:|||:.  |||.:|.|    .|.||    :......||:|  .......|..||..
 Worm   118 IPEEFEQKPSSSSHR--LPSEMNASITHIKSELDPTMQAFQMPHNDLFLATAAPHYNPFALSNDF 180

  Fly    69 GLSQQQQSVITLAMHGCSSTLPAQTTIIPINGNANGNGGSTNGQYVPGATNLGALANGMLNGGFN 133
            ..:....|.          |.|......|::.:..|:.|:|:     .:.|.|
 Worm   181 MPNPLMPSF----------TSPFYPQHFPVSDSRRGSQGTTS-----SSNNTG------------ 218

  Fly   134 GMQQQIQNGHGLINSTTPSTPTTPLHLQQNLGGAGGGGIGGMGILHHANGTPNGLIGVVGGGGGV 198
                      |..:..:.|.||:|..||
 Worm   219 ----------GTPSPHSSSLPTSPPQLQ------------------------------------- 236

  Fly   199 GLGVGGGGVGGLGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPRVQEEL 263
                     |.|.....|            |:||..:|. |..:..:.||.|            :
 Worm   237 ---------GFLRSFLNP------------DNLSTPTSF-GVPSETALDADK------------M 267

  Fly   264 CLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVG 328
            |.||.|||...||.|.|||||||||:|:|.|::.|.|...:.|.:|...|.:||.||.:|||.||
 Worm   268 CAVCNDRAVCLHYGARTCEGCKGFFKRTVQKNSKYTCAGNKTCPIDKRYRSRCQYCRYQKCLEVG 332

  Fly   329 MRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQ 393
            |..|.|                            :|   |||:...|:...|.:
 Worm   333 MVKEIV----------------------------RH---GSLSGRRGRLSSKTK----------- 355

  Fly   394 HATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEED------LRRIMSQPDEN 452
                       ||:.:.:..|.|..  ||::.|.|           ||      :|:.|...||.
 Worm   356 -----------LARSEDQPSPPLPL--LALMGKAI-----------EDHTNMTVVRQFMQPFDET 396

  Fly   453 ESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSD 517
                 ::.|.:......|.:|::    .:|..::|...|...||......:|.:|:|.|..:|:|
 Worm   397 -----IALRILHGELHATKKLLM----AMPQISEIQPADFQILLSRSFFAIMAIRVANRCGNSTD 452

  Fly   518 SIFFANNRSYTRDSYK---------MAGMADNIEDLLHFCRQMFSMKV------DNVEYALLTAI 567
            :|.|.:...::.:::.         |...|.....|:.:..|.|:..:      .|.|:.:|
 Worm   453 TIMFESGELFSLNAFPACFQQIIRFMVDKARTFSSLVDWEPQAFAAFIALQFLAGNTEHNVL--- 514

  Fly   568 VIFSDRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTE---LRTLGNQNA 629
                   ||....||:.:||..|:.|:     .||..|.:.:  ||::.:..|   ...||.|..
 Worm   515 -------GLTNKPLVDQVQSTIINALK-----DHCSGSQNKL--AKIVRLTQEFDVFHALGLQAL 565

  Fly   630 EMCFSLKLKNRKLPK 644
            ::.:    .:.:||:
 Worm   566 DILY----PSHQLPE 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	38/89 (43%)
		NR_LBD_EcR	420..652	CDD:132736	53/249 (21%)
nhr-6	NP_497731.1	Pax2_C	165..261	CDD:289189	27/191 (14%)
		NR_DBD_NGFI-B	266..340	CDD:143527	39/113 (35%)
		HOLI	405..560	CDD:214658	37/175 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910