Protein Alignment EcR and NR1H3

DIOPT Version :9

• Sequence 1: NP_001163061.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_024304052.1
• Gene: NR1H3 / 10062
• HGNCID: 7966
• Length: 511
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 173/520 - (33%)
• Similarity: 246/520 - (47%)
• Gaps: 131/520 - (25%)

  Fly   205 GGVGGLGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPR-VQEELCLVCG 268
            ||..|:|::   .::....::.......|:          ....:|.||||||: :..|||.|||
Human    51 GGTAGVGLE---AAEPTALLTRAEPPSEPT----------EIRPQKRKKGPAPKMLGNELCSVCG 102

  Fly   269 DRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPEC 333
            |:|||:|||.|:||||||||||||.|.|.|.|..|..|.||.|||||||||||:||...|||.||
Human   103 DKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREEC 167

  Fly   334 VVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIP 398
            |:.|.|..:|:  .|.|:|:....||                              .||:.::
Human   168 VLSEEQIRLKK--LKRQEEEQAHATS------------------------------LPPRASS-- 198

  Fly   399 LLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRI----MSQPDENESQTDVS 459
              |.:||        |.|:..||.:|.||:..|....:.|..|..|:    |:....:.......
Human   199 --PPQIL--------PQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQR 253

  Fly   460 FRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKA-------------------------- 498
            |.|.||:.|::||.||:|||.||.|.::.:||||.|||.
Human   254 FAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVAGEGQGMKGEAEWDYLWEGPP 318

  Fly   499 ------------------------CSS--------------EVMMLRMARRYDHSSDSIFFANNR 525
                                    ||.              :||:|..:|||:..|:||.|..:.
Human   319 DIELGEPNLLGSRDEENRPPWKRPCSKTSPPSPRLRFAACVQVMLLETSRRYNPGSESITFLKDF 383

  Fly   526 SYTRDSYKMAGM-ADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSY 588
            ||.|:.:..||: .:.|..:..|.|.|..:::::.|:|||.||.||| |||.::....||.:|..
Human   384 SYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHT 448

  Fly   589 YIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVH 653
            |::.|..|:...|..|.:   .:.::|..|..||||.:.::|..|:|:|:::|||..|.||||||
Human   449 YVEALHAYVSIHHPHDRL---MFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVH 510

  Fly   654  653
            Human   511  510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	57/89 (64%)
		NR_LBD_EcR	420..652	CDD:132736	90/301 (30%)
NR1H3	XP_024304052.1	NR_DBD_LXR	78..178	CDD:143534	62/99 (63%)
		NR_LBD_LXR	210..509	CDD:132752	90/301 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157559
Domainoid	1	1.000	129	1.000	Domainoid score	I5254
eggNOG	1	0.900	-	-		E33208_3BAC4
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5451
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1137281at2759
OrthoFinder	1	1.000	-	-		FOG0005880
OrthoInspector	1	1.000	-	-		otm41477
orthoMCL	1	0.900	-	-		OOG6_108995
Panther	1	1.100	-	-	LDO	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4275
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.700