DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EcR and rarb

DIOPT Version :9

Sequence 1:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_002932450.2	Gene:	rarb / 100488600	XenbaseID:	XB-GENE-481009	Length:	447	Species:	Xenopus tropicalis

Alignment Length:	491	Identity:	138/491 - (28%)
Similarity:	209/491 - (42%)	Gaps:	127/491 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 GVGGLGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPRVQEELCLVCGDR 270
            |:.....||...:.|:.:.|:..:||.||               .....|.||:.:. |.||.|:
Frog    39 GLAQTDWQHRHSAQSIETQSTSSEDLVPS---------------PPSPPPPPRIYKP-CFVCQDK 87

  Fly   271 ASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVV 335
            :|||||....|||||||||||:.|:.||.|...:.|.::...|.:||.|||::|..|||..|.|
Frog    88 SSGYHYGVSACEGCKGFFRRSIQKNMVYTCHREKNCVINKVTRNRCQYCRLQRCFEVGMSKESV- 151

  Fly   336 PENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLL 400
                   :....|.:||..|:....:.:                       ||.|         |
Frog   152 -------RNDRNKKKKEPSKIECIENYE-----------------------MTAE---------L 177

  Fly   401 PD--EILAKCQARNIPSL------TYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTD 457
            .|  |.:.|......|||      |.|..|                |:.:|..:...|:
Frog   178 DDLTEKIRKAHQETFPSLCQLGKYTTNSSA----------------EQRVRLDLGLWDK------ 220

  Fly   458 VSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFA 522
                 .:|:....:..||||||.||.||.:...||||||||...::::||:..||....|::.|:
Frog   221 -----FSELATKCIIKIVEFAKRLPGFTSLTIADQITLLKAACLDILILRICTRYTPEQDTMTFS 280

  Fly   523 NNRSYTRDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAI-VIFSDRPGLEKAQLVEAIQ 586
            :..:..|.....||.....:.:..|..|:..:::|:.|..||:|| :|..||..||:...|:.:|
Frog   281 DGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICEDRQDLEEPAKVDKLQ 345

  Fly   587 SYYIDTLRIYILNR-----HCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFL 646
            ...::.|:|||..|     |        .:.|:|..:|:||::..:.||...:|||   ::|
Frog   346 EPLLEALKIYIRKRRPNKPH--------MFPKILMKITDLRSISAKGAERVITLKL---EIP--- 396

  Fly   647 EEIWDVHAIPPSVQSHLQITQEENERLERAERMRAS 682
                  .::||.:|          |.||.:|...||
Frog   397 ------GSMPPLIQ----------EMLENSEGHEAS 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	38/89 (43%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	64/237 (27%)
rarb	XP_002932450.2	NR_DBD_RAR	75..159	CDD:143522	40/92 (43%)
rarb	XP_002932450.2	NR_LBD_RAR	179..409	CDD:132735	77/286 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910