Protein Alignment EcR and nr1d1

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001093675.1
• Gene: nr1d1 / 100101679
• XenbaseID: XB-GENE-478094
• Length: 522
• Species: Xenopus tropicalis
• Alignment Length: 574
• Identity: 152/574 - (26%)
• Similarity: 231/574 - (40%)
• Gaps: 140/574 - (24%)

  Fly   141 NGHGLIN--STTPSTP--TTPLHLQQNLGGAGGGGIGGMGILHHANGTP----NGLIGVVGGGGG 197
            |..|:|:  .::.|:|  |:|:.:..:.    ..|....|:.|:||..|    :.......|.||
 Frog     9 NTGGVISYVGSSGSSPNRTSPVSMYSDC----SSGSPQSGVSHYANYLPPSPSHSYSASSSGSGG 69

  Fly   198 -------VGLGVGGGGVGGLGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGP 255
                   .||....||:      |....|. :.:|..:.. |..:.|||...
 Frog    70 EASPRSSYGLAASPGGL------HVALDDG-SRVSPSKTS-SSITKLNGMVL------------- 113

  Fly   256 APRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVY--CCKFGRACEMDMYMRRKCQE 318
                   ||.||||.|||:||....|||||||||||:.::..|  |.| ...|.:....|.:||:
 Frog   114 -------LCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLK-NETCSIVRINRNRCQQ 170

  Fly   319 CRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASG---------- 373
            ||.:|||:|||..:.|         |..:..::||.:|.   :..|.....:|||
 Frog   171 CRFRKCLSVGMSRDAV---------RFGRIPKREKQRML---AEMHSAMNHIASGHFGRRSPIPL 223

  Fly   374 ----GGQDFVKKEILDLMTCEP--------------PQHATIPLLP-----DEILAKCQARNIPS 415
                ..|..:......||...|              ||..|.|..|     |:::::....:...
 Frog   224 QPHQQQQQQLHPSSSPLMGTAPCHSPTSLPDAYSQYPQQLTPPRSPSPEHMDDVISQVSMAHRQI 288

  Fly   416 LTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQP----DENESQTDVSFRHITEITIL------- 469
            ..|....|..|..|     :.|          ||    |..:|..:.:.|....:..|
 Frog   289 FVYANDKVNKKTSW-----DHP----------QPCWSHDTEDSHGNHNIRLACPMNALHRGGPVR 338

  Fly   470 ---------------TVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSI 519
                           .|:.:||||:.:|.|..:.|.||:|||||.:.||:|:|.|..:|....|:
 Frog   339 SVQEVWEDFSLSFTPAVREVVEFARHIPGFKDLTQNDQVTLLKAGTFEVLMVRFASLFDAREHSL 403

  Fly   520 FFANNRSYTRDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVE 583
            .|.:..:|:.......||.:.:..:..|..::.|:.:...|..:.||:|:.| ||.|:|.:.|||
 Frog   404 RFLSGATYSLPELHAMGMGELLSSMFDFSEKLSSLSLSQEELGIFTALVLVSADRSGMENSSLVE 468

  Fly   584 AIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKL 637
            .:|...|..||..||.....|:..   :.|||..|.:||||.|.::|...|.::
 Frog   469 QLQETLIRALRSLILKNSPNDTSR---FTKLLLRLPDLRTLNNMHSEKLLSFRV 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	39/91 (43%)
		NR_LBD_EcR	420..652	CDD:132736	68/245 (28%)
nr1d1	NP_001093675.1	NR_DBD_REV_ERB	110..198	CDD:143540	42/117 (36%)
		NR_LBD	331..519	CDD:472173	59/190 (31%)