DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IL1R1 and bdl

DIOPT Version :9

Sequence 1:	NP_000868.1	Gene:	IL1R1 / 3554	HGNCID:	5993	Length:	569	Species:	Homo sapiens
Sequence 2:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster

Alignment Length:	401	Identity:	97/401 - (24%)
Similarity:	141/401 - (35%)	Gaps:	101/401 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    56 TWYKDDSKTPVSTEQASRIHQHKE-KLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPN 119
            :||||........:...|.:...: .|...|..:.|.|.|.|.||||..  .::.:..|:    |
  Fly   183 SWYKDGVLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGEYECKVRNSDG--ELQTAKAFL----N 241

Human   120 LCYNAQAIFKQK---LPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGV---- 177
            :.|.|:.|:...   ||......|.|.:     ..|..|..|:|.||  .||.|:.:..||
  Fly   242 IQYKAKVIYAPPEVFLPYGQPAVLDCHF-----RANPPLKNLRWEKD--GLLFDSYNVPGVFYKM 299

Human   178 KDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVD-LG 241
            ...|....|.|.|.|:||| ..|..||...| :.||..|.|      ||.|.|...:.:.:. ||
  Fly   300 NGSLFFAKVDENHAGSYTC-TPYNDLGTDGP-SPVISVIVL------RPPIFSVTPKAIYIQKLG 356

Human   242 SQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSV------ENPANKRRSTL----ITVL 296
            ...:|.|                ..||.|    |.:..|:      ..|....|.:|    :|:.
  Fly   357 EAAELPC----------------EAIDRD----GNNRPSIIWGRKDGQPLPADRFSLSGGNLTIT 401

Human   297 NISEIESRFYKHPFTCFAKNTHGIDAAYIQL----IYPVT--NFQKHMIGICVTLTVIIVCSVFI 355
            .:.|.:...|:    |.|.|......|..:|    |.|..  |...:....|:|          |
  Fly   402 GLVEGDRGIYE----CSATNEAATITAEAELMIENIAPRAPYNLTANSTETCIT----------I 452

Human   356 -----YKIFKIDIVLWYR-DSCYDFLPIKASD-------------GKTYDAYILYPKTVGEGSTS 401
                 |....::..:||| ....::..::..|             ||.|:..:|.....|:|..|
  Fly   453 RWQPGYLRPNLEYTVWYRLMEAPEWRTLRVLDKKVMEATVQHLQPGKEYEFMVLSQDKYGDGMFS 517

Human   402 DCDIFVFKVLP 412
              ..|.|:.||
  Fly   518 --KQFRFQTLP 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IL1R1	NP_000868.1	Ig1_IL1R_like	24..113	CDD:319308	15/57 (26%)
		Ig2_IL1R_like	128..219	CDD:319309	30/97 (31%)
		IG	234..328	CDD:214652	20/108 (19%)
		TIR	384..540	CDD:214587	9/29 (31%)
bdl	NP_608822.1	IG_like	42..128	CDD:214653
		Ig	43..131	CDD:299845
		I-set	153..242	CDD:254352	16/64 (25%)
		Ig	157..242	CDD:299845	16/64 (25%)
		Ig_2	252..337	CDD:290606	29/93 (31%)
		IG_like	260..327	CDD:214653	24/74 (32%)
		I-set	341..428	CDD:254352	21/110 (19%)
		IGc2	356..419	CDD:197706	17/86 (20%)
		FN3	435..524	CDD:238020	19/100 (19%)
		FN3	554..636	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8188
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860