DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IL1R1 and ttn-1

DIOPT Version :9

Sequence 1:	NP_000868.1	Gene:	IL1R1 / 3554	HGNCID:	5993	Length:	569	Species:	Homo sapiens
Sequence 2:	NP_001346715.1	Gene:	ttn-1 / 266969	WormBaseID:	WBGene00006436	Length:	15188	Species:	Caenorhabditis elegans

Alignment Length:	324	Identity:	75/324 - (23%)
Similarity:	132/324 - (40%)	Gaps:	67/324 - (20%)

- Green bases have known domain annotations that are detailed below.

Human 22 KCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIH----QHKEKLW 82
||.|.: ||....| |...|.| .|.|::::|: :...|..|:. .....|.
Worm 13133 KCSESD---ILKLEVN-IQANPAP--------EINWFRNESE--IEHSQHHRLQFDDGSGNYSLT 13183

Human 83 FVPAKVEDSGHYYCVVRN------SSYCLRIK--IS--AKFVENEPNLCYNAQAIFKQKLPVAGD 137
.:.|..||||.|.||.:| :..|:||: :| :|.::......:..|....:::|...|
Worm 13184 IIDAYAEDSGEYKCVAKNKIGKAHTVCCVRIEELLSKRSKKIDGSKAPRFRMQLPTPREVPQGAD 13248

Human 138 GGLVC-----PYMEFFKNENNELPKLQWYKDCKPLLLDN---IHFSGVKDRLIVMNVAEKHRGNY 194
..||| |: |.::|.||.||:.:.| .|.:|| ..|.::...:..:|.|
Worm 13249 LTLVCSVSGTPH-----------PNIKWTKDDKPIDMSNKQVRHENGV-CTLHIIGARDDDQGRY 13301

Human 195 TCHASYTY-LGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQ-LSDI 257
.|.|...: :.:.:.:..:.|.: :....||..:.|.......: |:::.|.|.|||: :..|
Worm 13302 VCEAENIHGVAQSFSVVEIKEAV---DKDHVRPKFLEPLVNCSTCE-GNEMVLECCVTGKPIPTI 13362

Human 258 AYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGID 321
.::|....:|.|:..:...|...|.. :.::|:...:...| ||.|.|:.|.|
Worm 13363 TWYKDGLKLIIENRMLQYTDRKGVSR---------LNIMNVVMNDDGEY----TCEAVNSLGKD 13413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IL1R1	NP_000868.1	Ig1_IL1R_like	24..113	CDD:319308	26/102 (25%)
		Ig2_IL1R_like	128..219	CDD:319309	22/99 (22%)
		IG	234..328	CDD:214652	20/89 (22%)
		TIR	384..540	CDD:214587
ttn-1	NP_001346715.1	IG	105..177	CDD:214652
		I-set	205..285	CDD:333254
		I-set	406..493	CDD:333254
		I-set	821..914	CDD:333254
		Ig	962..1032	CDD:319273
		I-set	1135..1215	CDD:333254
		I-set	1679..1767	CDD:254352
		Ig	1789..>1845	CDD:319273
		Atrophin-1	<1957..2285	CDD:331285
		I-set	2381..2468	CDD:333254
		I-set	2489..2578	CDD:333254
		I-set	2631..2717	CDD:333254
		I-set	2732..2815	CDD:333254
		Ig	2848..2909	CDD:319273
		I-set	2924..3007	CDD:333254
		RNase_E_G	<3161..3303	CDD:331378
		RNase_E_G	<3356..3556	CDD:331378
		RNase_E_G	<3506..3673	CDD:331378
		RNase_E_G	<3595..3803	CDD:331378
		RNase_E_G	<3722..3912	CDD:331378
		RNase_E_G	<3875..4073	CDD:331378
		FtsK	<4014..>4556	CDD:332908
		RNase_E_G	<4346..4567	CDD:331378
		RNase_E_G	<4525..4723	CDD:331378
		RNase_E_G	<4746..4936	CDD:331378
		RNase_E_G	<4858..5044	CDD:331378
		FtsK	<4960..>5541	CDD:332908
		Neuromodulin_N	<5525..6250	CDD:331332
		Neuromodulin_N	<6198..6681	CDD:331332
		V-ATPase_G_2	<6559..>6683	CDD:330366
		I-set	7448..7535	CDD:333254
		FN3	7540..7630	CDD:238020
		MDN1	<7687..8197	CDD:331582
		Neuromodulin_N	<7944..8780	CDD:331332
		Ig	8886..>8935	CDD:325142
		FN3	9052..9142	CDD:238020
		Neuromodulin_N	<9210..9875	CDD:331332
		Neuromodulin_N	<9583..10392	CDD:331332
		IG_like	10597..>10662	CDD:214653
		Ig	10711..10773	CDD:325142
		FN3	10777..10870	CDD:238020
		FN3	10883..10958	CDD:238020
		FN3	10984..11070	CDD:238020
		I-set	11077..11165	CDD:333254
		IG	11179..11259	CDD:214652
		I-set	11264..11350	CDD:333254
		I-set	11368..11446	CDD:333254
		FN3	11450..11543	CDD:238020
		FN3	11565..11645	CDD:238020
		I-set	11823..11903	CDD:333254
		I-set	11918..11996	CDD:333254
		FN3	12006..12097	CDD:238020
		FN3	12131..12217	CDD:238020
		I-set	12225..12313	CDD:333254
		Ig	12337..12411	CDD:325142
		FN3	12415..12503	CDD:238020
		PKc_like	12566..12815	CDD:328722
		I-set	12894..12985	CDD:254352
		I-set	13024..13114	CDD:333254
		I-set	13123..13206	CDD:254352	24/86 (28%)
		Ig	13249..13314	CDD:319273	19/76 (25%)
		I-set	13331..13421	CDD:254352	22/97 (23%)
		I-set	13456..13545	CDD:254352
		I-set	13558..13650	CDD:254352
I-set	13663..13753	CDD:254352
FN3	13778..13864	CDD:238020
Ig	13893..13963	CDD:325142
I-set	13984..14074	CDD:333254
I-set	14083..14168	CDD:254352
Ig_3	14195..14275	CDD:316449
Ig_3	14302..14384	CDD:316449
I-set	14408..14498	CDD:333254
I-set	14634..14724	CDD:333254
IG_like	14754..14838	CDD:214653
I-set	14854..14943	CDD:333254
I-set	14969..15044	CDD:254352
Ig_3	15054..15132	CDD:316449
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910