Protein Alignment Ars2 and Srrt

DIOPT Version :10

• Sequence 1: NP_610203.2
• Gene: Ars2 / 35539
• FlyBaseID: FBgn0033062
• Length: 943
• Species: Drosophila melanogaster
• Sequence 2: NP_113582.1
• Gene: Srrt / 83701
• MGIID: 1933527
• Length: 875
• Species: Mus musculus
• Alignment Length: 1013
• Identity: 417/1013 - (41%)
• Similarity: 555/1013 - (54%)
• Gaps: 209/1013 - (20%)

  Fly     1 MGDSDDEYDRKRRDKFRGERESY-RTERRDDRRPVGGSAGARDEWAERNPFRGGASAGGGGARHR 64
            ||||||||||:||||||.||..| |:..||:||       ..|:|.:|...||..      .|.|
Mouse     1 MGDSDDEYDRRRRDKFRRERSDYDRSRERDERR-------RGDDWNDREWDRGRE------RRSR 52

  Fly    65 PDYSDYRGPGARPRYGSPVRDL-PPAKRMRPDWGDGDVRANPRFGGYD-PYL----------MQA 117
            .:|.|| ....|.|:..|..:| ||.||||.||.:..  ::|...||| ||.          .|.
Mouse    53 GEYRDY-DRNRRERFSPPRHELSPPQKRMRRDWDEHS--SDPYHSGYDMPYAGGGGGPTYGPPQP 114

  Fly   118 WN--DHYQSMHSAYSHGGHAPPVRESIGGGGGDTL--TQPAMLNLKQFLDTQDENISDSEVMRKY 178
            |.  |.:...|       |..|::..:|......|  ..|.|.:.|:||.:.|:::.::|.:::|
Mouse   115 WGHPDVHIMQH-------HVLPIQARLGSIAEIDLGVPPPIMKSFKEFLLSLDDSVDETEAVKRY 172

  Fly   179 TEYKTDFKRQQLNEFFVAHKDEEWFKNKYHPEDSVKRSEEQRGFLQRRTDVFMELLENGTIGSVK 243
            .:||.||:|||:.:||:||||||||::||||::..||.:|.||.||.|..||:.|:|:|...::.
Mouse   173 NDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLKVFLSLMESGWFDNLL 237

  Fly   244 VDSSQADALIRVLDTCVIKLEGGTDEDLKVLDEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEM 308
            :|..:|||::::||..|||:||||:.||::|              ||.:..::..||..:.|:|.
Mouse   238 LDIDKADAIVKMLDAAVIKMEGGTENDLRIL--------------EQEEEEEQAGKTGEASKKEE 288

  Fly   309 SEADPVSTQRKPVRPVN------SDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTK 367
            :.|.|...:.:  |..|      .||:..::|.:.:...||  :|...|.:.|.|:.:...||:|
Mouse   289 ARAGPALGEGE--RKANDKDEKKEDGKQAENDSSNDDKTKK--SEGDGDKEEKKEEAEKEAKKSK 349

  Fly   368 KRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDED 432
            ||.|..|.|||....|.|.|:.|.       |.|...|:|.|||    ||.|.|:.|:
Mouse   350 KRNRKQSGDDSFDEGSVSESESES-------EGGQAEEEKEEAE----EALKEKEKPK------- 396

  Fly   433 EGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETET 497
                                                          ||:.|||
Mouse   397 ----------------------------------------------EEEKEKP------------ 403

  Fly   498 IDLDKVKDG-----QPRALHRTSSIFLRNLAPSITRSEIEAVCNRFSGYLRVAIADPLVERRWYR 557
                  ||.     :||.||:|.|:|:||:||:|:|:||.::|.|:.|::|||:::|..|||::|
Mouse   404 ------KDAAGLECKPRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFR 462

  Fly   558 RGWITFMRDVNIKEICWGLNNQRLRDCEMGAIVNRDLSRRVRPANGITAHKQVVRSDIKLCAKIA 622
            |||:||.|.||||||||.|.|.|||:||:...|||||:||||..||||.|||:||:||||.||:.
Mouse   463 RGWVTFDRSVNIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLI 527

  Fly   623 LNLDEKFRLWAEGPKDDSNSARANESSENGSGST-YGFNSQNPVLQNITDYLIEEASAEEEELLG 686
            ..||::.:|||               ||.|:... ....||||:|:|||||||||.|||||||||
Mouse   528 HTLDDRTQLWA---------------SEPGTPPVPTSLPSQNPILKNITDYLIEEVSAEEEELLG 577

  Fly   687 LTG----ENKDTEGEP----IERDEQLISVLDRLVLYLRIVHSVDYYNHCEYPYEDEMPNRCGII 743
            .:|    |....||.|    :||||:||.|||:|:||||||||:||||.||||.|||||||||||
Mouse   578 SSGGPPPEEPPKEGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGII 642

  Fly   744 HARGP-PPVRVTNNDVQEYIKIYESKLQQFLTKTVPLSDEEIKNLGAKDAETEVEKFVQANTQEL 807
            |.||| ||.|:::.:|.|:.|.:|.||...|:....||:||.:.:|.||.|.||||||.:|||||
Mouse   643 HVRGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQEL 707

  Fly   808 AKDKWLCPLSGKKFKGPEFIRKHIFNKHEEKVDEVRKEVQYFNNYLRDPKRPQLPE-----HPGT 867
            .||||||||||||||||||:||||||||.||::||:|||.:|||:|.|.|||.|||     .||.
Mouse   708 GKDKWLCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGP 772

  Fly   868 SK------------------------RPESESARGGGGGYRPPM---YPPFSAMPYGFGPPMMGG 905
            ::                        :|.......|.|..||.:   .||:...|||.|......
Mouse   773 AQILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDA 837

  Fly   906 GRGGRNFP-PARRELPLEHQRRLIGYHDLDAPANSDMF 942
            .||...:| ..|..:.....|.::.|.|||||.:.|.|
Mouse   838 FRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ars2	NP_610203.2	SERRATE_Ars2_N	159..268	CDD:463453	52/108 (48%)
		ARS2	746..896	CDD:461498	85/182 (47%)
Srrt	NP_113582.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..90		46/104 (44%)
		SERRATE_Ars2_N	153..262	CDD:463453	52/108 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	272..411		50/224 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	571..597		12/25 (48%)
		ARS2	645..850	CDD:461498	92/204 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	834..853		4/18 (22%)