DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ars2 and SE

DIOPT Version :9

Sequence 1:	NP_610203.2	Gene:	Ars2 / 35539	FlyBaseID:	FBgn0033062	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_565635.1	Gene:	SE / 817252	AraportID:	AT2G27100	Length:	720	Species:	Arabidopsis thaliana

Alignment Length:	1059	Identity:	223/1059 - (21%)
Similarity:	299/1059 - (28%)	Gaps:	515/1059 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DDEYDRKRRDKFRGERESYRTERRDDR---RPVGGSAGARDEWAERNPFRGGASAGGGGARHRPD 66
            :.|.|:::. ..|.||:|  .||||:|   ||   ....|:.  :|:|.             .|.
plant    38 EQEQDQQQL-PLRRERDS--RERRDERDIERP---PPNRRER--DRSPL-------------PPP 81

  Fly    67 YSDY-RGPGARP-------RYGSPVRDLPPAKRMRPDWG--DGDVRANPRFGGYDPYLMQAWNDH 121
            ..|| |.|...|       |:..|.|..||.||.|.|..  ||. |.:|| |||.|...:...||
plant    82 RRDYKRRPSLSPPPPYRDRRHSPPQRRSPPQKRYRRDDNGYDGR-RGSPR-GGYGPPDRRFGYDH 144

  Fly   122 ---Y-QSMHSAYSHGGHAPPVR--------ESIGGGGGDTLT-----QPAMLNLKQFLDTQDENI 169
               | :.|.....:|...|..|        |...||.||...     :..:::.|||:...:::|
plant   145 GGGYDREMGGRPGYGDERPHGRFMGRYQDWEGGRGGYGDASNSGNPQRDGLMSYKQFIQELEDDI 209

  Fly   170 SDSEVMRKYTEYKTDFKRQQLNEFFVAHKDEEWFKNKYHPEDSVKRSEEQRGFLQRRTDVFMELL 234
            ..||..|:|.|||:::...|...||..||:|:|.||||||.:.:...|.:....|:....|:..|
plant   210 LPSEAERRYQEYKSEYITTQKRAFFNTHKEEDWLKNKYHPTNLLSVIERRNDLAQKVAKDFLLDL 274

  Fly   235 ENGTIGSVKVDSSQADALIRVLDTCVIKLEGGTDEDLKVLDEKPKDPVVYERKAEQMQSVKEVEK 299
            ::||:     |...|        ...:...|.|.|.    :.:.:...|.:||...|...||.|.
plant   275 QSGTL-----DLGPA--------VTALNKSGRTSEP----NSEDEAAGVGKRKRHGMGGAKENEL 322

  Fly   300 TINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKK 364
            ...:||.....:|                            ||:.|.
plant   323 LSAAPKAPSFTSD----------------------------PKRILT------------------ 341

  Fly   365 KTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKL 429
                                            |||......:|.::||               |:
plant   342 --------------------------------DVEQTQALVRKLDSEK---------------KI 359

  Fly   430 DEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVE 494
            :|                       |.|:                ||:.|:.|.:
plant   360 EE-----------------------NVLQ----------------GSETEKSGRE---------- 375

  Fly   495 TETIDLDKVKDGQPRALHRTSSIFLRNLAPSITRSEIEAVCNRFSGYLRVAIADPLVERRWYRRG 559
                           .||
plant   376 ---------------KLH----------------------------------------------- 378

  Fly   560 WITFMRDVNIKEICWGLNNQRLRDCEMGAIVNRDLSRRVRPANGITAHKQVVRSDIKLCAKIALN 624

plant   379 ----------------------------------------------------------------- 378

  Fly   625 LDEKFRLWAEGPKDDSNSARANESSENGSGSTYGFNSQNPVLQNITDYLIEEASAEEEELLGLTG 689
                                        ||||      .||:                .:.|||.
plant   379 ----------------------------SGST------GPVV----------------IIRGLTS 393

  Fly   690 ENKDTEGEPIERDEQLISVLDRLVLYLRIVHSVDYYNHCEYPYEDEMPNRC-GIIHARGPPPVRV 753
            . |..||         :.:||.||.||..||.:|||...|       .|.. |:.|.|....|..
plant   394 V-KGLEG---------VELLDTLVTYLWRVHGLDYYGKVE-------TNEAKGLRHVRAEGKVSD 441

  Fly   754 TNNDVQEYIKIYESKLQQFLTKTVPLSDEEIKNLGAKD----AETE-VEKFVQANTQELAKDKWL 813
            ...|..|  ..::|..|:.|....||   |:  :.||:    |.|| ::..|:....|....|:.
plant   442 AKGDENE--SKFDSHWQERLKGQDPL---EV--MAAKEKIDAAATEALDPHVRKIRDEKYGWKYG 499

  Fly   814 CPLSG--KKFKGPEFIRKHIFNKHEEKVDE----VRKEVQYFNNYLRDPKRP---QLPEHPGTSK 869
            |...|  |.|...||:.||:..||.|.|.|    ||:|: ||.||:.||..|   ...:..|...
plant   500 CGAKGCTKLFHAAEFVYKHLKLKHTELVTELTTKVREEL-YFQNYMNDPNAPGGQPATQQSGPRD 563

  Fly   870 RP--------------------------------ESE-----------------SARGGGGGYR- 884
            ||                                .||                 .|.||.||..
plant   564 RPIRRKPSMENRLRDDRGGRRERDGRANGNDRNDRSEDQQRGDNDGGNPGEVGYDAFGGQGGVHV 628

  Fly   885 ---------PPMY---------------PPFSAM-----PYGFGPPMMGGGRGGRN---FPPARR 917
                     |||.               ||..||     |.|..||..|.||||..   ..||.|
plant   629 PPFLSDINPPPMLMPVPGAGPLGPFVPAPPEVAMQMFRDPSGPNPPFEGSGRGGPAPFLLSPAFR 693

  Fly   918 ELPLEHQRRLIGYHDLDAP 936
            :.|    |||..|.|||||
plant   694 QDP----RRLRSYQDLDAP 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ars2	NP_610203.2	DUF3546	159..268	CDD:288886	33/108 (31%)
Ars2	NP_610203.2	ARS2	746..896	CDD:282772	58/242 (24%)
SE	NP_565635.1	DUF3546	199..>280	CDD:403330	30/85 (35%)
SE	NP_565635.1	ARS2	436..634	CDD:398562	50/205 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	66	1.000	Domainoid score	I3601
eggNOG	1	0.900	-	-		E1_KOG2295
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	148	1.000	Inparanoid score	I1724
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D525905at2759
OrthoFinder	1	1.000	-	-		FOG0005783
OrthoInspector	1	1.000	-	-		oto3654
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13165
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4173
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.060