DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ars2 and SRRT

DIOPT Version :9

Sequence 1:	NP_610203.2	Gene:	Ars2 / 35539	FlyBaseID:	FBgn0033062	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	XP_024302561.1	Gene:	SRRT / 51593	HGNCID:	24101	Length:	906	Species:	Homo sapiens

Alignment Length:	1043	Identity:	415/1043 - (39%)
Similarity:	554/1043 - (53%)	Gaps:	245/1043 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDSDDEYDRKRRDKFRGERESY-RTERRDDRRPVGGSAGARDEWAERNPFRGGASAGGGGARHR 64
            ||||||||||:||||||.||..| |:..||:||       ..|:|.:|...||..      .|.|
Human     8 MGDSDDEYDRRRRDKFRRERSDYDRSRERDERR-------RGDDWNDREWDRGRE------RRSR 59

  Fly    65 PDYSDYRGPGARPRYGSPVRDL-PPAKRMRPDWGDGDVRANPRFGGYD-PYL----------MQA 117
            .:|.|| ....|.|:..|..:| ||.||||.||.:..  ::|...||: ||.          .|.
Human    60 GEYRDY-DRNRRERFSPPRHELSPPQKRMRRDWDEHS--SDPYHSGYEMPYAGGGGGPTYGPPQP 121

  Fly   118 WN--DHYQSMHSAYSHGGHAPPVRESIGGGGGDTL--TQPAMLNLKQFLDTQDENISDSEVMRKY 178
            |.  |.:...|       |..|::..:|......|  ..|.|...|:||.:.|:::.::|.:::|
Human   122 WGHPDVHIMQH-------HVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRY 179

  Fly   179 TEYKTDFKRQQLNEFFVAHKDEEWFKNKYHPEDSVKRSEEQRGFLQRRTDVFMELLENGTIGSVK 243
            .:||.||:|||:.:||:||||||||::||||::..||.:|.||.||.|..||:.|:|.|...::.
Human   180 NDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLL 244

  Fly   244 VDSSQADALIRVLDTCVIKLEGGTDEDLKVLDE--------KPKDPVVYERKAEQMQS---VKEV 297
            :|..:|||::::||..|||:||||:.||::|::        ||.:|    .|.|:.::   :.:.
Human   245 LDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEP----SKKEEGRAGAGLGDG 305

  Fly   298 EKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLN 362
            |:..|. |:|..|                ||:..::|.:.:...||  :|...|.:.|.||.:..
Human   306 ERKTND-KDEKKE----------------DGKQAENDSSNDDKTKK--SEGDGDKEEKKEDSEKE 351

  Fly   363 KKK-----------------------------TKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDV 398
            .||                             :|||.|..|.|||....|.|.|:.|.
Human   352 AKKVRCLWPGVRVLGLGFWHADLSPLLWLTQSSKKRNRKHSGDDSFDEGSVSESESES------- 409

  Fly   399 EDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEIS 463
            |.|     :.|.||:..||.|.|:.|:
Human   410 ESG-----QAEEEKEEAEALKEKEKPK-------------------------------------- 431

  Fly   464 SNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLDKVKDG-----QPRALHRTSSIFLRNLA 523
                           ||:.|||                  ||.     :||.||:|.|:|:||:|
Human   432 ---------------EEEWEKP------------------KDAAGLECKPRPLHKTCSLFMRNIA 463

  Fly   524 PSITRSEIEAVCNRFSGYLRVAIADPLVERRWYRRGWITFMRDVNIKEICWGLNNQRLRDCEMGA 588
            |:|:|:||.::|.|:.|::|||:::|..|||::||||:||.|.||||||||.|.|.|||:||:..
Human   464 PNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNIRLRECELSP 528

  Fly   589 IVNRDLSRRVRPANGITAHKQVVRSDIKLCAKIALNLDEKFRLWAEGPKDDSNSARANESSENGS 653
            .|||||:||||..||||.|||:||:||||.||:...||::.:|||               ||.|:
Human   529 GVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWA---------------SEPGT 578

  Fly   654 GS-TYGFNSQNPVLQNITDYLIEEASAEEEELLGLTG----ENKDTEGEP----IERDEQLISVL 709
            .. .....||||:|:|||||||||.|||||||||.:|    |....||.|    :||||:||.||
Human   579 PPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVERDEKLIKVL 643

  Fly   710 DRLVLYLRIVHSVDYYNHCEYPYEDEMPNRCGIIHARGP-PPVRVTNNDVQEYIKIYESKLQQFL 773
            |:|:||||||||:||||.||||.||||||||||||.||| ||.|:::.:|.|:.|.:|.||...|
Human   644 DKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLEWQKTFEEKLTPLL 708

  Fly   774 TKTVPLSDEEIKNLGAKDAETEVEKFVQANTQELAKDKWLCPLSGKKFKGPEFIRKHIFNKHEEK 838
            :....||:||.:.:|.||.|.||||||.:|||||.||||||||||||||||||:||||||||.||
Human   709 SVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGPEFVRKHIFNKHAEK 773

  Fly   839 VDEVRKEVQYFNNYLRDPKRPQLPE-----HPGTSK--------------------RPESESARG 878
            ::||:|||.:|||:|.|.|||.|||     .||.::                    :|.......
Human   774 IEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQSLTPGLPYPHQTPQGLMPYGQPRPPILGY 838

  Fly   879 GGGGYRPPM---YPPFSAMPYGFGPPMMGGGRGGRNFP-PARRELPLEHQRRLIGYHDLDAPANS 939
            |.|..||.:   .||:...|||.|.......||...:| ..|..:.....|.::.|.|||||.:.
Human   839 GAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDV 903

  Fly   940 DMF 942
            |.|
Human   904 DFF 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ars2	NP_610203.2	DUF3546	159..268	CDD:288886	52/108 (48%)
Ars2	NP_610203.2	ARS2	746..896	CDD:282772	85/178 (48%)
SRRT	XP_024302561.1	DUF3546	160..269	CDD:314875	52/108 (48%)
SRRT	XP_024302561.1	ARS2	680..881	CDD:309888	92/200 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158508
Domainoid	1	1.000	308	1.000	Domainoid score	I1346
eggNOG	1	0.900	-	-		E1_KOG2295
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9298
Inparanoid	1	1.050	654	1.000	Inparanoid score	I784
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48601
OrthoDB	1	1.010	-	-		D184508at33208
OrthoFinder	1	1.000	-	-		FOG0005783
OrthoInspector	1	1.000	-	-		oto90564
orthoMCL	1	0.900	-	-		OOG6_103709
Panther	1	1.100	-	-	LDO	PTHR13165
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2818
SonicParanoid	1	1.000	-	-		X4173
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840