DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ars2 and srrt

DIOPT Version :9

Sequence 1:	NP_610203.2	Gene:	Ars2 / 35539	FlyBaseID:	FBgn0033062	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_775345.2	Gene:	srrt / 192311	ZFINID:	ZDB-GENE-020419-13	Length:	896	Species:	Danio rerio

Alignment Length:	1013	Identity:	418/1013 - (41%)
Similarity:	567/1013 - (55%)	Gaps:	188/1013 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDSDDEYDRKRRDKFRGERESY-RTERRDDRRPVGGSAGARDEWAERNPFRGGASA----GGGG 60
            ||||||||||:||||||.||..| |:..|:|||        ||:|.:|.|     ||    .|..
Zfish     1 MGDSDDEYDRRRRDKFRRERSDYDRSREREDRR--------RDDWNDRRP-----SAREWDRGRE 52

  Fly    61 ARHRPDYSDYRGPGARPRYGSPVRDL-PPAKRMRPDWGD--GDVRANPRFGGYD----------- 111
            .|.|.:|.|| ..|.|.|:..|..|: |..||||.||.|  ||    |..||||
Zfish    53 RRSRGEYRDY-DRGRRERFSPPRHDMSPQQKRMRRDWDDHGGD----PYHGGYDLGYGGGGGPSY 112

  Fly   112 --PYLMQAWNDHYQSMHSAYSHGGHAPPVRESIGGGGGDTL--TQPAMLNLKQFLDTQDENISDS 172
              |   |.|.  :..||....|  |..|::..:|......|  ..|.|...|:||.:.|:::.::
Zfish   113 APP---QPWG--HPDMHLMQPH--HGIPIQARLGNIHDMDLGPPPPVMKTFKEFLISLDDSVDET 170

  Fly   173 EVMRKYTEYKTDFKRQQLNEFFVAHKDEEWFKNKYHPEDSVKRSEEQRGFLQRRTDVFMELLENG 237
            |.:::|.|||.||:|||:.:||:||||||||::||||:::.:|..|....||.|..|:|.|::|.
Zfish   171 ESVKRYNEYKIDFRRQQMQDFFLAHKDEEWFRSKYHPDEAGRRKAEAHSALQNRLGVYMYLMDNN 235

  Fly   238 TIGSVKVDSSQADALIRVLDTCVIKLEGGTDEDLKVLDEKPKDPVVYERKAEQMQSVKEVEKTIN 302
            ...||.:|..:|..:.::||..|||:|||.:.||::|::    |...|.:.|::.|.       .
Zfish   236 WFESVSLDIERAPQITKILDAAVIKMEGGAENDLRILEQ----PSEEEEERERLSSG-------G 289

  Fly   303 SPKE--EMSEADPVSTQRKPVRPVN--SDGENWDDDDAENS----APKKELAEDSKDSDSKPEDK 359
            :|.|  :..|..|..|:.||....:  .:||...:.|.|.:    :..:|..|....::..||.|
Zfish   290 TPSEPSKRDEPKPADTENKPSEEKDKMEEGEESAEKDGEKASAGGSEGEEKTEKEAPAEPIPEPK 354

  Fly   360 QLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGP 424
            :|:||: |::....|:|::|:|||.|.||.:        .:...:|:.:|.|::.:|
Zfish   355 KLSKKR-KRKHSGDSEDEASASESESDSDSD--------SNSHCSEKPSEREREPEE-------- 402

  Fly   425 QSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGK 489
                ::|.|..|..|.:..|.|..|.|:.:.                       |::.||
Zfish   403 ----VEEKEEEEEEEGEAADGKEQTDEQTER-----------------------EKEKEK----- 435

  Fly   490 DKVVETETIDLDKVKDGQ---PRALHRTSSIFLRNLAPSITRSEIEAVCNRFSGYLRVAIADPLV 551
                        ||||.|   ||.||||.|:|:|::||:|:::||.|:|.|:.|::||.:::|..
Zfish   436 ------------KVKDDQPPRPRPLHRTCSLFMRSIAPTISKAEIVALCRRYPGFMRVCLSEPQP 488

  Fly   552 ERRWYRRGWITFMRDVNIKEICWGLNNQRLRDCEMGAIVNRDLSRRVRPANGITAHKQVVRSDIK 616
            |||::||.|:||.|.||||||||.|.|.||||||:...|||||:||||..||||.||||:|:|||
Zfish   489 ERRFFRRCWVTFDRGVNIKEICWNLQNIRLRDCELAPGVNRDLARRVRNVNGITQHKQVLRNDIK 553

  Fly   617 LCAKIALNLDEKFRLWAEGPKDDSNSARANESSENGSGSTYGFNSQNPVLQNITDYLIEEASAEE 681
            |.||:...||::.:||::.|::::              .|....:|||:|:|||||||||.||||
Zfish   554 LAAKLIHALDDREKLWSQKPREET--------------PTLELPAQNPILKNITDYLIEEVSAEE 604

  Fly   682 EELLGLTG----ENKDTEGEP----IERDEQLISVLDRLVLYLRIVHSVDYYNHCEYPYEDEMPN 738
            |||||..|    |:...||.|    :||||:|:.|||||:.|||||||:||||.||||.||||||
Zfish   605 EELLGSAGGGDSEDGSKEGNPTEITVERDEKLVKVLDRLLFYLRIVHSIDYYNTCEYPSEDEMPN 669

  Fly   739 RCGIIHARGP-PPVRVTNNDVQEYIKIYESKLQQFLTKTVPLSDEEIKNLGAKDAETEVEKFVQA 802
            ||||||.||| ||.|:|..:|.::.|.:|.|:....:....||::|...:|.||.|.||||||.|
Zfish   670 RCGIIHVRGPIPPNRITLREVSDWQKTFEEKMGPLFSVKENLSEDEAAKMGRKDPEQEVEKFVVA 734

  Fly   803 NTQELAKDKWLCPLSGKKFKGPEFIRKHIFNKHEEKVDEVRKEVQYFNNYLRDPKRPQLPE---- 863
            |||||.||||||||||||||||||:||||.|||.:|::||:|||.:|||:|.|.|||.:||
Zfish   735 NTQELGKDKWLCPLSGKKFKGPEFVRKHILNKHGDKIEEVKKEVVFFNNFLMDAKRPCIPEMKPP 799

  Fly   864 -HPGTSK----------RPESESARGGGGGYRPPMYPPFSAMPYGFGPP----MMGGGRGG-RNF 912
             |||..:          .|:......|.|..|||:      |.||.|||    ..|||||. .||
Zfish   800 PHPGPGQGVLSPGGLPFPPQGPQGLMGFGQPRPPL------MGYGGGPPYPPNQYGGGRGNYDNF 858

  Fly   913 --------PPARRELPLEHQRRLIGYHDLDAPANSDMF 942
                    .|....:.....|.:|.|.|||||.:.|.|
Zfish   859 RGQGGYPGKPRNSRVMRGDPRNIIEYRDLDAPDDVDFF 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ars2	NP_610203.2	DUF3546	159..268	CDD:288886	49/108 (45%)
Ars2	NP_610203.2	ARS2	746..896	CDD:282772	81/165 (49%)
srrt	NP_775345.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92		50/104 (48%)
		DUF3546	157..266	CDD:288886	49/108 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..450		59/253 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..628		8/20 (40%)
		ARS2	677..870	CDD:282772	94/198 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	850..877		7/26 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594457
Domainoid	1	1.000	313	1.000	Domainoid score	I1270
eggNOG	1	0.900	-	-		E1_KOG2295
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	673	1.000	Inparanoid score	I709
OMA	1	1.010	-	-		QHG48601
OrthoDB	1	1.010	-	-		D184508at33208
OrthoFinder	1	1.000	-	-		FOG0005783
OrthoInspector	1	1.000	-	-		oto40251
orthoMCL	1	0.900	-	-		OOG6_103709
Panther	1	1.100	-	-	LDO	PTHR13165
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2818
SonicParanoid	1	1.000	-	-		X4173
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800