DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ars2 and E01A2.2

DIOPT Version :9

Sequence 1:	NP_610203.2	Gene:	Ars2 / 35539	FlyBaseID:	FBgn0033062	Length:	943	Species:	Drosophila melanogaster
Sequence 2:	NP_491302.1	Gene:	E01A2.2 / 171996	WormBaseID:	WBGene00017085	Length:	712	Species:	Caenorhabditis elegans

Alignment Length:	978	Identity:	322/978 - (32%)
Similarity:	452/978 - (46%)	Gaps:	312/978 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDSDDEYDRKRRDKFRGERESYRTERRDDRRPVGGSAGARDEWAERNPFRGGASAGGGGARHRP 65
            |.||||:.|| |||||..||                    |||     .:|.|   |||..|:
Worm     1 MVDSDDDGDR-RRDKFARER--------------------RDE-----DYRRG---GGGFNRY-- 34

  Fly    66 DYSDYRGPGARPRYGSPVRDLPPAKRMRPDWGDGDVRANPRFGGYDPYLMQAWNDHYQSMHSAYS 130
               |.:.||.|       ||....||.|.|  |.|       ..:||.             |...
Worm    35 ---DNKRPGGR-------RDDYQVKRSRGD--DAD-------DSFDPV-------------SRSG 67

  Fly   131 HGGHAPPVRESIGGGGGDTLTQPAMLNLKQFLDTQDENISDSEVMRKYTEYKTDFKRQQLNEFFV 195
            :|...|...:||..|        .:...|:||.:|:::||:.:.::||.||||:.::.||..||.
Worm    68 NGSDLPTESDSIYSG--------PLQTFKKFLTSQEDDISEEDAIKKYNEYKTEHRKHQLERFFR 124

  Fly   196 AHKDEEWFKNKYHPEDSVKRSEEQRGFLQRRTDVFMELLENGTIGSVKVDSSQADALIRVLDTCV 260
            ||||||||:.||.|:|:.|..|.....:|:|..||.||.|.|......:|...|:|:||:||:.|
Worm   125 AHKDEEWFRLKYKPDDAKKLREAHLENVQKRLQVFNELKEQGQFNKFSLDFGDAEAIIRMLDSVV 189

  Fly   261 IKLEGGTDEDLK-VLDEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPV 324
            :|||.||:::|| ||.:|.:|           :|:.:::|
Worm   190 VKLENGTEDELKAVLAQKLED-----------ESLADIKK------------------------- 218

  Fly   325 NSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDE 389
                   |::......||:|           ||.||                     ||.::
Worm   219 -------DENGNGTEQPKEE-----------PEVKQ---------------------ESGAT--- 241

  Fly   390 EKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEID 454
            |:|:|. .:|||
Worm   242 EELEEG-AIEDG----------------------------------------------------- 252

  Fly   455 NTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLDKVKDGQPRALHRTSSIFL 519
                 .|.|||.:.                                          :|||.|:||
Worm   253 -----TEKSSNKVN------------------------------------------IHRTCSVFL 270

  Fly   520 RNLAPSITRSEIEAVCNRFSGYLRVAIADPLVERRWYRRGWITFMRDVNIKEICWGLNNQRLRDC 584
            ||:.|.:|..|:|.:|.:..|:||:|:.|.:.||::|||||.||.||:|||||||.||..|||:.
Worm   271 RNIPPGLTYEELEGLCKKSPGFLRLALTDGIAERKFYRRGWATFKRDINIKEICWALNAHRLRET 335

  Fly   585 EMGAIVNRDLSRRVRPANGITAHKQVVRSDIKLCAKIALNLDEKFRLWAEGPKDDSNSARANESS 649
            ::.||:|||::||||..|||.:||||..:|:||..|:.:..|:|..|:     :.::.|.|:...
Worm   336 DLNAIINRDITRRVRTNNGIASHKQVAINDLKLAVKLTVLYDKKIGLF-----NAADEADADREM 395

  Fly   650 ENGSGSTYGFNSQNPVLQNITDY----LIEEASAEEEELLGLT-GENKDTEGEPIERDEQLISVL 709
            :...|......|.||:::.:...    ::.:.|.||.||||:: |.....|....|||:.::..|
Worm   396 DIRMGVDLVAASTNPLIKEVKSLVPHDVLNDISEEEAELLGVSNGGEAPAEKIRFERDDNILKAL 460

  Fly   710 DRLVLYLRIVHSVDYYNHCEYPYEDEMPNRCGIIHARGPPP--VRVTNND----------VQEYI 762
            |.|::|||||||:|:|||..|..||.||||||:||.||.||  |.:|.::          |.::|
Worm   461 DLLIVYLRIVHSIDFYNHGHYAQEDSMPNRCGLIHVRGQPPSGVSITTDEDGALVVPQKFVNDFI 525

  Fly   763 KIYESKLQQFLTKTVPLSDEEIKNLGAKDAETEVEKFVQANTQELAKDKWLCPLSGKKFKGPEFI 827
            ..:.|::::.|.:...:|:||::.:|.||.|.|||.|:|.||.||||||||||||||||||||||
Worm   526 SGFNSRIEKGLIEKQYVSEEELEKMGKKDGEKEVEAFIQKNTVELAKDKWLCPLSGKKFKGPEFI 590

  Fly   828 RKHIFNKHEEKVDEVRKEVQYFNNYLRDPKRP------QLP----------EHPGTSKRPESESA 876
            |||:.:|||:|::|.|.|..:|||||.|.:||      |.|          |..|..:..:.:..
Worm   591 RKHLQSKHEDKLEEARAEADFFNNYLADAQRPVDCEPKQAPRDDHRGGGGGERGGYGRERDDDRG 655

  Fly   877 RG-------GGGGY-RPPMYPPFSAMPYGFGPPMMGGGRGGRNFPPARRELPLEHQRRLIGYHDL 933
            .|       ||||| |.|.:||..::.        |.|.|||.|..|.|..|       :.|.||
Worm   656 PGGGGRNSFGGGGYDRRPQFPPRHSLG--------GRGGGGRYFEDAPRRQP-------VSYRDL 705

  Fly   934 DAP 936
            |||
Worm   706 DAP 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ars2	NP_610203.2	DUF3546	159..268	CDD:288886	50/108 (46%)
Ars2	NP_610203.2	ARS2	746..896	CDD:282772	78/185 (42%)
E01A2.2	NP_491302.1	DUF3546	88..197	CDD:288886	50/108 (46%)
E01A2.2	NP_491302.1	ARS2	497..>634	CDD:282772	66/136 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166133
Domainoid	1	1.000	233	1.000	Domainoid score	I1364
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9298
Inparanoid	1	1.050	400	1.000	Inparanoid score	I1099
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48601
OrthoDB	1	1.010	-	-		D184508at33208
OrthoFinder	1	1.000	-	-		FOG0005783
OrthoInspector	1	1.000	-	-		oto18998
orthoMCL	1	0.900	-	-		OOG6_103709
Panther	1	1.100	-	-	LDO	PTHR13165
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2818
SonicParanoid	1	1.000	-	-		X4173
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940