DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SmydA-5 and ZMYND15

DIOPT Version :9

Sequence 1:	NP_610202.3	Gene:	SmydA-5 / 35538	FlyBaseID:	FBgn0033061	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001254751.1	Gene:	ZMYND15 / 84225	HGNCID:	20997	Length:	750	Species:	Homo sapiens

Alignment Length:	396	Identity:	84/396 - (21%)
Similarity:	115/396 - (29%)	Gaps:	157/396 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 CRLGKHQCRR-----CRW-----PVCSAGCKHESMECSVLSLGSGS-----PTRADARSLNDYFR 152
            ||..:.|.||     ..|     |..|.|          :|||.|:     |....|..|.|.
Human    40 CRQLEAQIRRLPQDPALWVLHVLPNHSVG----------ISLGQGAEPGPGPGLGTAWLLGDN-- 92

  Fly   153 GDALLVLKCLLLQRQSPTKWSALLEMQSHEEERKGTDLYEEAEKR---------VVTYLQKRFLC 208
                   ..|.|:..||  :.:.:.::..||..:..:..||.|||         .|...:.|.|.
Human    93 -------PPLHLRDLSP--YISFVSLEDGEEGEEEEEEDEEEEKREDGGAGSTEKVEPEEDRELA 148

  Fly   209 RLKQTNPNLLTDCGPEMLHRLCGIIETNFMVIELPSGVELSGLFRQACMMEHACQPNCDFQFDNK 273
            ...:.:|.                 |||      |.| |.....|:|...:..|:.:   :.:|:
Human   149 PTSRESPQ-----------------ETN------PPG-ESEEAAREAGGGKDGCRED---RVENE 186

  Fly   274 TQQVAVRAGCDLRKGDHLRITYTNILWGTQLRQHHLRLTKHFSCRCSRCLDPTEYGTYISALTCL 338
            |:.       ..|||                 |.......|.||   ..|...|:||.:
Human   187 TRP-------QKRKG-----------------QRSEAAPLHVSC---LLLVTDEHGTIL------ 218

  Fly   339 GDVNQTCGGTHLPVDPLDENTQWKCDT----------------CPM------------IVDGAYV 375
                    |..|.||.......|...|                |||            :.|....
Human   219 --------GIDLLVDGAQGTASWGSGTKDLAPWAYALLCHSMACPMGSGDPRKPRQLTVGDARLH 275

  Fly   376 AELQSHMTEQVEGLLAGCPSAN-------QVELLLARLTHMLHPNHFHTFNLKHT-----LIQLY 428
            .||:| :..::...||..|...       ....|.||..|:.|.   |:|..|.|     ...||
Human   276 RELES-LVPRLGVKLAKTPMRTWGPRPGFTFASLRARTCHVCHR---HSFEAKLTPCPQCSAVLY 336

  Fly   429 GNEAGL 434
            ..||.|
Human   337 CGEACL 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-5	NP_610202.3	zf-MYND	7..43	CDD:280009
SmydA-5	NP_610202.3	SET	185..295	CDD:279228	23/118 (19%)
ZMYND15	NP_001254751.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..199		26/140 (19%)
		zf-MYND	313..359	CDD:280009	11/33 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..590
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..750
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830