DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SmydA-5 and smyd4

DIOPT Version :9

Sequence 1:	NP_610202.3	Gene:	SmydA-5 / 35538	FlyBaseID:	FBgn0033061	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_012812690.1	Gene:	smyd4 / 779741	XenbaseID:	XB-GENE-945037	Length:	777	Species:	Xenopus tropicalis

Alignment Length:	521	Identity:	101/521 - (19%)
Similarity:	168/521 - (32%)	Gaps:	183/521 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DAELGRYLKVTQNIAAGQIVFIEEPL--VVGP---------KWYLSDADKEASNVPCVGCYT--- 101
            |...||:|..:|||..|:::..||..  |:.|         ||   |....|.:..|..|..
Frog   246 DTRKGRHLLASQNIEQGEVLIWEEAFASVIIPERKQWRKEIKW---DTRITACDHYCHYCLNRVI 307

  Fly   102 ---PCRLGKHQCRRCRWPVCSAGC------KHESMECS----VLSLGSGSPTRADARSLNDYFRG 153
               ||:    .|...|:  ||..|      .:..:|||    :|:||....|..
Frog   308 ASLPCQ----YCSFARY--CSQECMDKAWRSYHYIECSMGDLLLALGMFCHTAL----------- 355

  Fly   154 DALLVLKCLLLQRQSPTKWSA-----------------------------LLEMQSHEEERK--- 186
            .|:||..|.|..:......||                             |...::|..|||
Frog   356 RAVLVAGCRLFSQSLEQTGSADATDKTKVCNSKNTYHEKYCSSYQSVVNLLPHTENHPAERKFLC 420

  Fly   187 ---GTDLYEEAEKRVVTYLQKRFLCRLKQTNPNLLTD-------------CGPEMLHRLCGII-- 233
               ...||    |::...:.|..:....||..:|..:             .||.:|..:..:.
Frog   421 GLTAAALY----KKLCLIMAKDLVSSTSQTEKSLTKESGTIEDWSSVRQFLGPTVLRHMLQLYCN 481

  Fly   234 ------------ETNFMVIELPSGVEL-SGLFRQACMMEHACQPNCDFQFDNKTQQVAVRAGCDL 285
                        |::..:::....:.| :.:|....::.|:|.||....|..:.  |.|||...:
Frog   482 AQAVTALQENEDESSLSLVKSNKSIRLATAVFPVLSLLNHSCDPNTTVSFTGRF--VTVRANRPI 544

  Fly   286 RKGDHLRITY--TNILWGTQLRQHHLRLTKHFSCRCSRCLDPTE----YGTYI----------SA 334
            |:.:.:...|  ..:......||..|:....|.|:|..|.:..:    :|.:.          .|
Frog   545 RRDEEVTHCYGPHKLRMDVAERQQLLKDQYFFVCQCKACTEELKGKKTHGFFCPLCKAQLEGEEA 609

  Fly   335 LTCLG--------------DVNQTCGGTHLPVDPLDENTQWKCDTCPMIVDGAYVAELQSHMTEQ 385
            |.|.|              .:||.  |.|:.:..:                     :||.:.|:.
Frog   610 LYCTGARCTYTASQTQLTSRLNQL--GNHIQIAKV---------------------QLQDNKTDN 651

  Fly   386 VEGLLAGCPS-----ANQVELLLARLTHMLHPNHFHTFNLK----H-----TLIQLYGNEAGLEL 436
            .:..|..|.|     .:|..|||..:...|........|.|    |     ::::::...:.:||
Frog   652 AKMTLMSCLSEAECFLSQDHLLLGEIMDHLAQAEASDGNWKAAAGHLRKSISIVKVHYGSSSMEL 716

  Fly   437 G 437
            |
Frog   717 G 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-5	NP_610202.3	zf-MYND	7..43	CDD:280009
SmydA-5	NP_610202.3	SET	185..295	CDD:279228	25/143 (17%)
smyd4	XP_012812690.1	TPR repeat	106..134	CDD:276809
		TPR_11	107..170	CDD:290150
		TPR repeat	143..173	CDD:276809
		zf-MYND	299..338	CDD:280009	9/44 (20%)
		SET	<509..555	CDD:279228	11/47 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910