DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SmydA-5 and smyd1b

DIOPT Version :9

Sequence 1:	NP_610202.3	Gene:	SmydA-5 / 35538	FlyBaseID:	FBgn0033061	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001034725.1	Gene:	smyd1b / 569027	ZFINID:	ZDB-GENE-060522-1	Length:	486	Species:	Danio rerio

Alignment Length:	383	Identity:	80/383 - (20%)
Similarity:	146/383 - (38%)	Gaps:	100/383 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GRYLKVTQNIAAGQIVFIEEPL--VVGPKWYLSDADKEASNVPCVGCYTPCRLGKHQ-CRRCRW- 115
            ||.|:.|:...||.::|.|.|.  ||        .|.:||:: |..|:.  |..|.| |.:||:
Zfish    13 GRGLRATKEAWAGDVLFAEPPFASVV--------FDSQASSI-CHSCFR--RQEKLQRCGQCRFA 66

  Fly   116 ----PVCS-AGCKHESMECSVLSLGSGSPTRADARSLNDYFRGDALLVLKCLLLQRQ-------S 168
                ..|. ||.:...:||:.:.. .|.|...:.|             |...:|.|.       |
Zfish    67 QYCDKTCQRAGWEEHKLECAAIKT-YGKPPSENVR-------------LAARILWRMDKQGSVVS 117

  Fly   169 PTKWSALLEMQSH-----EEERKG--TDLYEEAEKRVVTYLQKRFLCRLKQTNPNLLTDCGPEML 226
            ..:.:.|.:::.|     |::.|.  .|::     ..:.|..       :.:.|:.:     :.:
Zfish   118 DNQLTTLEDLEDHICDISEDDLKDFKVDIH-----NFLDYWP-------RNSKPHTV-----DSV 165

  Fly   227 HRLCGIIETNFMVIELPSGVEL--SGLFRQACMMEHACQPNCDFQFDNKTQ-----------QVA 278
            ..:.|:|..|..::....|::.  .|||...|::.|.|.|||....:|..|           ::.
Zfish   166 SHILGVINCNGFMVSDQRGLQAVGVGLFPNLCLVNHDCWPNCTVILNNGNQSAIDTVFHSQKRIE 230

  Fly   279 VRAGCDLRKGDHLRITYTNILWGTQLRQHHLRLTKHFSCRCSRCLDPTEYGTYISALTCLGDVNQ 343
            :||...:..|:.:.:.|.:.|..:..||..|:....|.|.|..|.:.            :.|..:
Zfish   231 LRALGKISAGEEVTVAYVDYLNVSADRQRLLKQQYFFDCTCKHCTEK------------IKDDLK 283

  Fly   344 TCG----GTHLPVDPLDENTQW------KCDTCPMIVDGAYVAELQSHMTEQVEGLLA 391
            ..|    |..:|.:.:.|.|::      |.:...:..:...|.::.....|:.|.:||
Zfish   284 MAGAEVDGVKVPEEQVKEVTEFSRQKLEKMEKARIEANYNEVVKICRECVEKQENVLA 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-5	NP_610202.3	zf-MYND	7..43	CDD:280009
SmydA-5	NP_610202.3	SET	185..295	CDD:279228	22/124 (18%)
smyd1b	NP_001034725.1	zf-MYND	47..85	CDD:280009	11/39 (28%)
smyd1b	NP_001034725.1	SET	<173..247	CDD:214614	16/73 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582767
Domainoid	1	1.000	54	1.000	Domainoid score	I11197
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D981799at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750